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The Diagnostic Challenge of an Infrequent Spectrum of Cryptococcus Infection

Cryptococcal infection results from inhalation of fungal spores and usually is confined to the lungs, but may disseminate systemically. Radiologically, cryptococcal infection has multiple forms of presentation. The diagnosis is usually based on fungal isolation from cultured clinical specimens. Long...

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Autores principales: Barbosa De Araujo Neto, Francisco, Corona De Godoy Bueno, Camila, Tambelini Gomes, Liege, Alejandra Ortiz Navas, Daniela, Wanderley, Mark, Gallotti Borges Carneiro, Stefanie, Karine Veras Gomes De Mello, Rita, Mendes Coura, Laura, Sayuri Missumi, Larissa, Durante, Henrique, Cintra Zagatti, Ricardo Francisco, Sawamura, Márcio Valente Yamada
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334315/
https://www.ncbi.nlm.nih.gov/pubmed/30719369
http://dx.doi.org/10.1155/2019/5970648
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author Barbosa De Araujo Neto, Francisco
Corona De Godoy Bueno, Camila
Tambelini Gomes, Liege
Alejandra Ortiz Navas, Daniela
Wanderley, Mark
Gallotti Borges Carneiro, Stefanie
Karine Veras Gomes De Mello, Rita
Mendes Coura, Laura
Sayuri Missumi, Larissa
Durante, Henrique
Cintra Zagatti, Ricardo Francisco
Sawamura, Márcio Valente Yamada
author_facet Barbosa De Araujo Neto, Francisco
Corona De Godoy Bueno, Camila
Tambelini Gomes, Liege
Alejandra Ortiz Navas, Daniela
Wanderley, Mark
Gallotti Borges Carneiro, Stefanie
Karine Veras Gomes De Mello, Rita
Mendes Coura, Laura
Sayuri Missumi, Larissa
Durante, Henrique
Cintra Zagatti, Ricardo Francisco
Sawamura, Márcio Valente Yamada
author_sort Barbosa De Araujo Neto, Francisco
collection PubMed
description Cryptococcal infection results from inhalation of fungal spores and usually is confined to the lungs, but may disseminate systemically. Radiologically, cryptococcal infection has multiple forms of presentation. The diagnosis is usually based on fungal isolation from cultured clinical specimens. Long term antifungal therapy is recommended, but surgical procedures may eventually be necessary when large thoracic symptomatic masses are present. We report a case of a 41-year-old male, immunocompetent, investigating a palpable mass in the left supraclavicular region associated with unintentional weight loss over the last three months. He also reported chest pain in this period. Chest X-ray, ultrasonography, and computed tomography were performed, which diagnosed a mediastinal and left supraclavicular mass, interpreted as lymph node conglomerates of unknown etiology. He also underwent a biopsy of the left supraclavicular mass for etiological determination by histopathology, which confirmed cryptococcosis infection. Although very infrequent, mediastinal cryptococcal infection (simulating masses) is a challenging but important differential diagnosis of benign and malignant lesions, since its treatment is usually clinical.
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spelling pubmed-63343152019-02-04 The Diagnostic Challenge of an Infrequent Spectrum of Cryptococcus Infection Barbosa De Araujo Neto, Francisco Corona De Godoy Bueno, Camila Tambelini Gomes, Liege Alejandra Ortiz Navas, Daniela Wanderley, Mark Gallotti Borges Carneiro, Stefanie Karine Veras Gomes De Mello, Rita Mendes Coura, Laura Sayuri Missumi, Larissa Durante, Henrique Cintra Zagatti, Ricardo Francisco Sawamura, Márcio Valente Yamada Case Rep Radiol Case Report Cryptococcal infection results from inhalation of fungal spores and usually is confined to the lungs, but may disseminate systemically. Radiologically, cryptococcal infection has multiple forms of presentation. The diagnosis is usually based on fungal isolation from cultured clinical specimens. Long term antifungal therapy is recommended, but surgical procedures may eventually be necessary when large thoracic symptomatic masses are present. We report a case of a 41-year-old male, immunocompetent, investigating a palpable mass in the left supraclavicular region associated with unintentional weight loss over the last three months. He also reported chest pain in this period. Chest X-ray, ultrasonography, and computed tomography were performed, which diagnosed a mediastinal and left supraclavicular mass, interpreted as lymph node conglomerates of unknown etiology. He also underwent a biopsy of the left supraclavicular mass for etiological determination by histopathology, which confirmed cryptococcosis infection. Although very infrequent, mediastinal cryptococcal infection (simulating masses) is a challenging but important differential diagnosis of benign and malignant lesions, since its treatment is usually clinical. Hindawi 2019-01-02 /pmc/articles/PMC6334315/ /pubmed/30719369 http://dx.doi.org/10.1155/2019/5970648 Text en Copyright © 2019 Francisco Barbosa De Araujo Neto et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Barbosa De Araujo Neto, Francisco
Corona De Godoy Bueno, Camila
Tambelini Gomes, Liege
Alejandra Ortiz Navas, Daniela
Wanderley, Mark
Gallotti Borges Carneiro, Stefanie
Karine Veras Gomes De Mello, Rita
Mendes Coura, Laura
Sayuri Missumi, Larissa
Durante, Henrique
Cintra Zagatti, Ricardo Francisco
Sawamura, Márcio Valente Yamada
The Diagnostic Challenge of an Infrequent Spectrum of Cryptococcus Infection
title The Diagnostic Challenge of an Infrequent Spectrum of Cryptococcus Infection
title_full The Diagnostic Challenge of an Infrequent Spectrum of Cryptococcus Infection
title_fullStr The Diagnostic Challenge of an Infrequent Spectrum of Cryptococcus Infection
title_full_unstemmed The Diagnostic Challenge of an Infrequent Spectrum of Cryptococcus Infection
title_short The Diagnostic Challenge of an Infrequent Spectrum of Cryptococcus Infection
title_sort diagnostic challenge of an infrequent spectrum of cryptococcus infection
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334315/
https://www.ncbi.nlm.nih.gov/pubmed/30719369
http://dx.doi.org/10.1155/2019/5970648
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