OCT4 maintains self-renewal and reverses senescence in human hair follicle mesenchymal stem cells through the downregulation of p21 by DNA methyltransferases

BACKGROUND: Self-renewal is dependent on an intrinsic gene regulatory network centered on OCT4 and on an atypical cell cycle G1/S transition, which is also regulated by OCT4. p21, a gene negatively associated with self-renewal and a senescence marker, is a member of the universal cyclin-dependent ki...

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Detalles Bibliográficos
Autores principales: Lu, Yan, Qu, Huinan, Qi, Da, Xu, Wenhong, Liu, Shutong, Jin, Xiangshu, Song, Peiye, Guo, Yantong, Jia, Yiyang, Wang, Xinqi, Li, Hairi, Li, Yulin, Quan, Chengshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334457/
https://www.ncbi.nlm.nih.gov/pubmed/30646941
http://dx.doi.org/10.1186/s13287-018-1120-x

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