The long non-coding RNA Kcnq1ot1 controls maternal p57 expression in muscle cells by promoting H3K27me3 accumulation to an intragenic MyoD-binding region

BACKGROUND: The cell-cycle inhibitor p57(kip2) plays a critical role in mammalian development by coordinating cell proliferation and differentiation in many cell types. p57(kip2) expression is finely regulated by several epigenetic mechanisms, including paternal imprinting. Kcnq1ot1, a long non-codi...

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Detalles Bibliográficos
Autores principales: Andresini, Oriella, Rossi, Marianna Nicoletta, Matteini, Francesca, Petrai, Stefano, Santini, Tiziana, Maione, Rossella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334472/
https://www.ncbi.nlm.nih.gov/pubmed/30651140
http://dx.doi.org/10.1186/s13072-019-0253-1

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