Enhancers active in dopamine neurons are a primary link between genetic variation and neuropsychiatric disease

Enhancers function as DNA logic gates and may control specialized functions of billions of neurons. Here we show a tailored program of noncoding genome elements active in situ in physiologically distinct dopamine neurons of the human brain. We found 71,022 transcribed noncoding elements, many of whi...

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Detalles Bibliográficos
Autores principales: Dong, Xianjun, Liao, Zhixiang, Gritsch, David, Hadzhiev, Yavor, Bai, Yunfei, Locascio, Joseph J, Guennewig, Boris, Liu, Ganqiang, Blauwendraat, Cornelis, Wang, Tao, Adler, Charles H, Hedreen, John C, Faull, Richard L M, Frosch, Matthew P, Nelson, Peter T, Rizzu, Patrizia, Cooper, Antony A, Heutink, Peter, Beach, Thomas G, Mattick, John S, Müller, Ferenc, Scherzer, Clemens R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334654/
https://www.ncbi.nlm.nih.gov/pubmed/30224808
http://dx.doi.org/10.1038/s41593-018-0223-0

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