Epigenetic mechanism and target therapy of UHRF1 protein complex in malignancies

Ubiquitin-like with plant homeodomain and really interesting new gene finger domains 1 (UHRF1) functions as an epigenetic regulator recruiting PCNA, DNMT1, histone deacetylase 1, G9a, SuV39H, herpes virus-associated ubiquitin-specific protease, and Tat-interactive protein by multiple corresponding d...

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Autores principales: Xue, Busheng, Zhao, Jiansong, Feng, Penghui, Xing, Jia, Wu, Hongliang, Li, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334784/
https://www.ncbi.nlm.nih.gov/pubmed/30666134
http://dx.doi.org/10.2147/OTT.S192234
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author Xue, Busheng
Zhao, Jiansong
Feng, Penghui
Xing, Jia
Wu, Hongliang
Li, Yan
author_facet Xue, Busheng
Zhao, Jiansong
Feng, Penghui
Xing, Jia
Wu, Hongliang
Li, Yan
author_sort Xue, Busheng
collection PubMed
description Ubiquitin-like with plant homeodomain and really interesting new gene finger domains 1 (UHRF1) functions as an epigenetic regulator recruiting PCNA, DNMT1, histone deacetylase 1, G9a, SuV39H, herpes virus-associated ubiquitin-specific protease, and Tat-interactive protein by multiple corresponding domains of DNA and H3 to maintain DNA methylation and histone modifications. Overexpression of UHRF1 has been found as a potential biomarker in various cancers resulting in either DNA hypermethylation or global DNA hypo-methylation, which participates in the occurrence, progression, and invasion of cancer. The role of UHRF1 in the reciprocal interaction between DNA methylation and histone modifications, the dynamic structural transformation of UHRF1 protein within epigenetic code replication machinery in epigenetic regulations, as well as modifications during cell cycle and chemotherapy targeting UHRF1 are evaluated in this study.
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spelling pubmed-63347842019-01-21 Epigenetic mechanism and target therapy of UHRF1 protein complex in malignancies Xue, Busheng Zhao, Jiansong Feng, Penghui Xing, Jia Wu, Hongliang Li, Yan Onco Targets Ther Review Ubiquitin-like with plant homeodomain and really interesting new gene finger domains 1 (UHRF1) functions as an epigenetic regulator recruiting PCNA, DNMT1, histone deacetylase 1, G9a, SuV39H, herpes virus-associated ubiquitin-specific protease, and Tat-interactive protein by multiple corresponding domains of DNA and H3 to maintain DNA methylation and histone modifications. Overexpression of UHRF1 has been found as a potential biomarker in various cancers resulting in either DNA hypermethylation or global DNA hypo-methylation, which participates in the occurrence, progression, and invasion of cancer. The role of UHRF1 in the reciprocal interaction between DNA methylation and histone modifications, the dynamic structural transformation of UHRF1 protein within epigenetic code replication machinery in epigenetic regulations, as well as modifications during cell cycle and chemotherapy targeting UHRF1 are evaluated in this study. Dove Medical Press 2019-01-11 /pmc/articles/PMC6334784/ /pubmed/30666134 http://dx.doi.org/10.2147/OTT.S192234 Text en © 2019 Xue et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
Xue, Busheng
Zhao, Jiansong
Feng, Penghui
Xing, Jia
Wu, Hongliang
Li, Yan
Epigenetic mechanism and target therapy of UHRF1 protein complex in malignancies
title Epigenetic mechanism and target therapy of UHRF1 protein complex in malignancies
title_full Epigenetic mechanism and target therapy of UHRF1 protein complex in malignancies
title_fullStr Epigenetic mechanism and target therapy of UHRF1 protein complex in malignancies
title_full_unstemmed Epigenetic mechanism and target therapy of UHRF1 protein complex in malignancies
title_short Epigenetic mechanism and target therapy of UHRF1 protein complex in malignancies
title_sort epigenetic mechanism and target therapy of uhrf1 protein complex in malignancies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334784/
https://www.ncbi.nlm.nih.gov/pubmed/30666134
http://dx.doi.org/10.2147/OTT.S192234
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