Synthesis of a tubugi-1-toxin conjugate by a modulizable disulfide linker system with a neuropeptide Y analogue showing selectivity for hY1R-overexpressing tumor cells

Tubugi-1 is a small cytotoxic peptide with picomolar cytotoxicity. To improve its cancer cell targeting, it was conjugated using a universal, modular disulfide derivative. This allowed conjugation to a neuropeptide-Y (NPY)-inspired peptide [K(4)(C-βA-),F(7),L(17),P(34)]-hNPY, acting as NPY Y1 recept...

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Detalles Bibliográficos
Autores principales: Kufka, Rainer, Rennert, Robert, Kaluđerović, Goran N, Weber, Lutz, Richter, Wolfgang, Wessjohann, Ludger A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2019
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334802/
https://www.ncbi.nlm.nih.gov/pubmed/30680044
http://dx.doi.org/10.3762/bjoc.15.11

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334802/
https://www.ncbi.nlm.nih.gov/pubmed/30680044
http://dx.doi.org/10.3762/bjoc.15.11

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