Cargando…

Synthesis of a tubugi-1-toxin conjugate by a modulizable disulfide linker system with a neuropeptide Y analogue showing selectivity for hY1R-overexpressing tumor cells

Tubugi-1 is a small cytotoxic peptide with picomolar cytotoxicity. To improve its cancer cell targeting, it was conjugated using a universal, modular disulfide derivative. This allowed conjugation to a neuropeptide-Y (NPY)-inspired peptide [K(4)(C-βA-),F(7),L(17),P(34)]-hNPY, acting as NPY Y1 recept...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kufka, Rainer, Rennert, Robert, Kaluđerović, Goran N, Weber, Lutz, Richter, Wolfgang, Wessjohann, Ludger A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Beilstein-Institut 2019
Materias:	Full Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334802/ https://www.ncbi.nlm.nih.gov/pubmed/30680044 http://dx.doi.org/10.3762/bjoc.15.11

Ejemplares similares

In Vitro Anticancer Screening and Preliminary Mechanistic Study of A-Ring Substituted Anthraquinone Derivatives
por: Morgan, Ibrahim, et al.
Publicado: (2022)

Chlorambucil Conjugated Ugi Dendrimers with PAMAM-NH(2) Core and Evaluation of Their Anticancer Activity
por: Seixas, Nalin, et al.
Publicado: (2019)

Characterisation of Neuropeptide Y Receptor Subtypes by Synthetic NPY Analogues and by Anti-receptor Antibodies‡
por: Eckard, Christophe P., et al.
Publicado: (2001)

Drug Delivery System for Emodin Based on Mesoporous Silica SBA-15
por: Krajnović, Tamara, et al.
Publicado: (2018)

In Vitro Evaluation of Antiproliferative Properties of Novel Organotin(IV) Carboxylate Compounds with Propanoic Acid Derivatives on a Panel of Human Cancer Cell Lines
por: Pantelić, Nebojša Đ., et al.
Publicado: (2021)

Neuropeptide Y protocols /
Publicado: (2000)

Synthesis of (−)-julocrotine and a diversity oriented Ugi-approach to analogues and probes
por: Neves Filho, Ricardo A W, et al.
Publicado: (2011)

Structural basis of neuropeptide Y signaling through Y1 receptor
por: Park, Chaehee, et al.
Publicado: (2022)

Phosphonylated Acyclic Guanosine Analogues with the 1,2,3-Triazole Linker
por: Głowacka, Iwona E., et al.
Publicado: (2015)

Anticancer Potential of Xanthohumol and Isoxanthohumol Loaded into SBA-15 Mesoporous Silica Particles against B16F10 Melanoma Cells
por: Krajnović, Tamara, et al.
Publicado: (2022)

The membrane bound aromatic p-hydroxybenzoic acid oligoprenyltransferase (UbiA) - how iterative improvements lead to a realistic structure that offers new insights into functional aspects of prenyl transferases and terpene synthases
por: Brandt, W, et al.
Publicado: (2010)

A peptide triple agonist of GLP-1, neuropeptide Y1, and neuropeptide Y2 receptors promotes glycemic control and weight loss
por: Chichura, Kylie S., et al.
Publicado: (2023)

Structural basis of ligand binding modes at the neuropeptide Y Y(1) receptor
por: Yang, Zhenlin, et al.
Publicado: (2018)

Exploring of the property of epoxy resins based on diselenide and disulfide dynamic linkers
por: Wei, Xiao, et al.
Publicado: (2022)

The multicomponent approach to N-methyl peptides: total synthesis of antibacterial (–)-viridic acid and analogues
por: Neves Filho, Ricardo A W, et al.
Publicado: (2012)

Author Correction: Structural basis of neuropeptide Y signaling through Y1 receptor
por: Park, Chaehee, et al.
Publicado: (2022)

Neuropeptides at the crossroad of fear and hunger: a special focus on neuropeptide Y
por: Comeras, Lucas B., et al.
Publicado: (2019)

Conjugation of Doxorubicin to siRNA Through Disulfide-based Self-immolative Linkers
por: Gauthier, Florian, et al.
Publicado: (2020)

The Role of Neuropeptide Y in the Nucleus Accumbens
por: Tanaka, Masaki, et al.
Publicado: (2021)

Neuropeptide Y inhibits the trigeminovascular pathway through NPY Y(1) receptor: implications for migraine
por: Oliveira, Margarida-Martins, et al.
Publicado: (2016)

Neuropeptide Y in the medial habenula alleviates migraine-like behaviors through the Y1 receptor
por: Yang, Chunxiao, et al.
Publicado: (2023)

Neuropeptide Y reduces expression of social fear via simultaneous activation of Y1 and Y2 receptors
por: Kornhuber, Johannes, et al.
Publicado: (2019)

Neuropeptide Y1 receptor antagonist but not neuropeptide Y itself increased bone mineral density when locally injected with hyaluronic acid in male Wistar rats
por: ÇEVİK, Muhammer Özgür, et al.
Publicado: (2020)

A fundamental bimodal role for neuropeptide Y1 receptor in the immune system
por: Wheway, Julie, et al.
Publicado: (2005)

Neuropeptide Y inhibits interleukin-1β-induced phagocytosis by microglial cells
por: Ferreira, Raquel, et al.
Publicado: (2011)

Bioactive Phenolic Compounds from Peperomia obtusifolia
por: Ware, Ismail, et al.
Publicado: (2022)

Neuropeptide Y: Biomarker and intervention for surgical recovery
por: Zhao, Dong Fang, et al.
Publicado: (2015)

The fat regulator neuropeptide Y and caloric restriction
por: Park, Seongjoon, et al.
Publicado: (2017)

The Role of Neuropeptide Y in Cardiovascular Health and Disease
por: Tan, Cheryl M. J., et al.
Publicado: (2018)

Roles of Neuropeptide Y in Neurodegenerative and Neuroimmune Diseases
por: Li, Chunrong, et al.
Publicado: (2019)

Neuropeptide Y in Alcohol Addiction and Affective Disorders
por: Thorsell, Annika, et al.
Publicado: (2017)

Neuropeptide Y Is an Immunomodulatory Factor: Direct and Indirect
por: Chen, Wei-can, et al.
Publicado: (2020)

Pharmacological inhibition of neuropeptide Y receptors Y1 and Y5 reduces hypoxic breast cancer migration, proliferation, and signaling
por: Pascetta, Sydney A., et al.
Publicado: (2023)

Structural basis for ligand recognition of the neuropeptide Y Y(2) receptor
por: Tang, Tingting, et al.
Publicado: (2021)

The neuropeptide Y Y1 receptor knockdown modulates activator protein 1-involved feeding behavior in amphetamine-treated rats
por: Hsieh, Yih-Shou, et al.
Publicado: (2013)

Allosteric modulation of peptide ligand binding to Neuropeptide Y receptor Y1 revealed by fluorescence-based assay
por: Veiksina, Santa, et al.
Publicado: (2015)

Spinal neuropeptide Y Y1 receptor-expressing neurons are a pharmacotherapeutic target for the alleviation of neuropathic pain
por: Nelson, Tyler S., et al.
Publicado: (2022)

Endogenous μ-opioid—Neuropeptide Y Y1 receptor synergy silences chronic postoperative pain in mice
por: Nelson, Tyler S, et al.
Publicado: (2023)

A disulfide-based linker for thiol–norbornene conjugation: formation and cleavage of hydrogels by the use of light
por: Lunzer, Markus, et al.
Publicado: (2022)

ProSAAS-Derived Peptides are Colocalized with Neuropeptide Y and Function as Neuropeptides in the Regulation of Food Intake
por: Wardman, Jonathan H., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_hf95h9c90ldp65dl6srs3vuinp