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Regioselective addition of Grignard reagents to N-acylpyrazinium salts: synthesis of substituted 1,2-dihydropyrazines and Δ(5)-2-oxopiperazines

The regioselective addition of Grignard reagents to mono- and disubstituted N-acylpyrazinium salts affording substituted 1,2-dihydropyrazines in modest to excellent yields (45–100%) is described. Under acidic conditions, these 1,2-dihydropyrazines can be converted to substituted Δ(5)-2-oxopiperazine...

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Detalles Bibliográficos
Autores principales:	St. Hilaire, Valentine R, Hopkins, William E, Miller, Yenteeo S, Dandepally, Srinivasa R, Williams, Alfred L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Beilstein-Institut 2019
Materias:	Full Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334805/ https://www.ncbi.nlm.nih.gov/pubmed/30680041 http://dx.doi.org/10.3762/bjoc.15.8

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