Thymoma-associated Myasthenia Gravis in a Young Adult with Development of Paraneoplastic Limbic Encephalitis and Systemic Lupus Erythematosus Post-thymectomy: A Case Report

We report a young adult with thymoma-associated myasthenia gravis (MG) who, following thymectomy, developed paraneoplastic limbic encephalitis (LE) and systemic lupus erythematosus (SLE). Although thymomas commonly co-occur with MG, LE is an uncommon autoimmune sequela. Herein, we discuss the pathop...

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Autores principales: Liu, Robin, Dar, A. Rashid, Tay, Keng Yeow, Nicolle, Mike W, Inculet, Richard I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2018
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334889/
https://www.ncbi.nlm.nih.gov/pubmed/30656085
http://dx.doi.org/10.7759/cureus.3581
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author Liu, Robin
Dar, A. Rashid
Tay, Keng Yeow
Nicolle, Mike W
Inculet, Richard I
author_facet Liu, Robin
Dar, A. Rashid
Tay, Keng Yeow
Nicolle, Mike W
Inculet, Richard I
author_sort Liu, Robin
collection PubMed
description We report a young adult with thymoma-associated myasthenia gravis (MG) who, following thymectomy, developed paraneoplastic limbic encephalitis (LE) and systemic lupus erythematosus (SLE). Although thymomas commonly co-occur with MG, LE is an uncommon autoimmune sequela. Herein, we discuss the pathophysiology of paraneoplastic LE and its management. Our report also highlights an unusual case of a thymoma patient who presented with multiple autoimmune disorders. The treatment of such a patient is therefore challenging and requires care from multiple specialized teams.
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spelling pubmed-63348892019-01-17 Thymoma-associated Myasthenia Gravis in a Young Adult with Development of Paraneoplastic Limbic Encephalitis and Systemic Lupus Erythematosus Post-thymectomy: A Case Report Liu, Robin Dar, A. Rashid Tay, Keng Yeow Nicolle, Mike W Inculet, Richard I Cureus Internal Medicine We report a young adult with thymoma-associated myasthenia gravis (MG) who, following thymectomy, developed paraneoplastic limbic encephalitis (LE) and systemic lupus erythematosus (SLE). Although thymomas commonly co-occur with MG, LE is an uncommon autoimmune sequela. Herein, we discuss the pathophysiology of paraneoplastic LE and its management. Our report also highlights an unusual case of a thymoma patient who presented with multiple autoimmune disorders. The treatment of such a patient is therefore challenging and requires care from multiple specialized teams. Cureus 2018-11-13 /pmc/articles/PMC6334889/ /pubmed/30656085 http://dx.doi.org/10.7759/cureus.3581 Text en Copyright © 2018, Liu et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Liu, Robin
Dar, A. Rashid
Tay, Keng Yeow
Nicolle, Mike W
Inculet, Richard I
Thymoma-associated Myasthenia Gravis in a Young Adult with Development of Paraneoplastic Limbic Encephalitis and Systemic Lupus Erythematosus Post-thymectomy: A Case Report
title Thymoma-associated Myasthenia Gravis in a Young Adult with Development of Paraneoplastic Limbic Encephalitis and Systemic Lupus Erythematosus Post-thymectomy: A Case Report
title_full Thymoma-associated Myasthenia Gravis in a Young Adult with Development of Paraneoplastic Limbic Encephalitis and Systemic Lupus Erythematosus Post-thymectomy: A Case Report
title_fullStr Thymoma-associated Myasthenia Gravis in a Young Adult with Development of Paraneoplastic Limbic Encephalitis and Systemic Lupus Erythematosus Post-thymectomy: A Case Report
title_full_unstemmed Thymoma-associated Myasthenia Gravis in a Young Adult with Development of Paraneoplastic Limbic Encephalitis and Systemic Lupus Erythematosus Post-thymectomy: A Case Report
title_short Thymoma-associated Myasthenia Gravis in a Young Adult with Development of Paraneoplastic Limbic Encephalitis and Systemic Lupus Erythematosus Post-thymectomy: A Case Report
title_sort thymoma-associated myasthenia gravis in a young adult with development of paraneoplastic limbic encephalitis and systemic lupus erythematosus post-thymectomy: a case report
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334889/
https://www.ncbi.nlm.nih.gov/pubmed/30656085
http://dx.doi.org/10.7759/cureus.3581
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