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Flubendazole as a macrofilaricide: History and background
Benzimidazole anthelmintics have long been employed for the control of soil-transmitted helminth infections. Flubendazole (FBZ) was approved in 1980 for the treatment of gastrointestinal nematode infections in both veterinary and human medicine. It has also long been known that parenteral administra...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334891/ https://www.ncbi.nlm.nih.gov/pubmed/30650160 http://dx.doi.org/10.1371/journal.pntd.0006436 |
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author | Geary, Timothy G. Mackenzie, Charles D. Silber, Steven A. |
author_facet | Geary, Timothy G. Mackenzie, Charles D. Silber, Steven A. |
author_sort | Geary, Timothy G. |
collection | PubMed |
description | Benzimidazole anthelmintics have long been employed for the control of soil-transmitted helminth infections. Flubendazole (FBZ) was approved in 1980 for the treatment of gastrointestinal nematode infections in both veterinary and human medicine. It has also long been known that parenteral administration of FBZ can lead to high macrofilaricidal efficacy in a variety of preclinical models and in humans. As part of an effort to stimulate the discovery and development of new macrofilaricides, particularly for onchocerciasis, research has recently been devoted to the development of new formulations that would afford high oral bioavailability of FBZ, paving the way for potential clinical development of this repurposed drug for the treatment of human filariases. This review summarizes the background information that led to this program and summarizes some of the lessons learned from it. |
format | Online Article Text |
id | pubmed-6334891 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-63348912019-01-31 Flubendazole as a macrofilaricide: History and background Geary, Timothy G. Mackenzie, Charles D. Silber, Steven A. PLoS Negl Trop Dis Historical Profiles and Perspectives Benzimidazole anthelmintics have long been employed for the control of soil-transmitted helminth infections. Flubendazole (FBZ) was approved in 1980 for the treatment of gastrointestinal nematode infections in both veterinary and human medicine. It has also long been known that parenteral administration of FBZ can lead to high macrofilaricidal efficacy in a variety of preclinical models and in humans. As part of an effort to stimulate the discovery and development of new macrofilaricides, particularly for onchocerciasis, research has recently been devoted to the development of new formulations that would afford high oral bioavailability of FBZ, paving the way for potential clinical development of this repurposed drug for the treatment of human filariases. This review summarizes the background information that led to this program and summarizes some of the lessons learned from it. Public Library of Science 2019-01-16 /pmc/articles/PMC6334891/ /pubmed/30650160 http://dx.doi.org/10.1371/journal.pntd.0006436 Text en © 2019 Geary et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Historical Profiles and Perspectives Geary, Timothy G. Mackenzie, Charles D. Silber, Steven A. Flubendazole as a macrofilaricide: History and background |
title | Flubendazole as a macrofilaricide: History and background |
title_full | Flubendazole as a macrofilaricide: History and background |
title_fullStr | Flubendazole as a macrofilaricide: History and background |
title_full_unstemmed | Flubendazole as a macrofilaricide: History and background |
title_short | Flubendazole as a macrofilaricide: History and background |
title_sort | flubendazole as a macrofilaricide: history and background |
topic | Historical Profiles and Perspectives |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334891/ https://www.ncbi.nlm.nih.gov/pubmed/30650160 http://dx.doi.org/10.1371/journal.pntd.0006436 |
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