Short-course, oral flubendazole does not mediate significant efficacy against Onchocerca adult male worms or Brugia microfilariae in murine infection models

The Onchocerca ochengi adult implant and Brugia malayi microfilariemic Severe-Combined Immunodeficient (SCID) mouse models are validated screens to measure macrofilaricidal and microfilaricidal activities of candidate onchocerciasis drugs. The purpose of this study was to assess whether 5 daily sub-...

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Detalles Bibliográficos
Autores principales: Sjoberg, Hanna T., Pionnier, Nicolas, Aljayyoussi, Ghaith, Metuge, Haelly M., Njouendou, Abdel J., Chunda, Valerine C., Fombad, Fanny F., Tayong, Dizzle B., Gandjui, Narcisse V. T., Akumtoh, Desmond N., Chounna, Patrick W. N., Ndzeshang, Bertrand L., Lachaud, Sophie, Tekle, Fetene, Quirynen, Ludo, Engelen, Marc, Baeten, Benny, Steven, Andrew, Ward, Stephen A., Taylor, Mark J., Wanji, Samuel, Turner, Joseph D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334903/
https://www.ncbi.nlm.nih.gov/pubmed/30650071
http://dx.doi.org/10.1371/journal.pntd.0006356

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