GPI-anchor signal sequence influences PrP(C) sorting, shedding and signalling, and impacts on different pathomechanistic aspects of prion disease in mice

The cellular prion protein (PrP(C)) is a cell surface glycoprotein attached to the membrane by a glycosylphosphatidylinositol (GPI)-anchor and plays a critical role in transmissible, neurodegenerative and fatal prion diseases. Alterations in membrane attachment influence PrP(C)-associated signaling,...

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Detalles Bibliográficos
Autores principales: Puig, Berta, Altmeppen, Hermann C., Linsenmeier, Luise, Chakroun, Karima, Wegwitz, Florian, Piontek, Ulrike K., Tatzelt, Jörg, Bate, Clive, Magnus, Tim, Glatzel, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334958/
https://www.ncbi.nlm.nih.gov/pubmed/30608982
http://dx.doi.org/10.1371/journal.ppat.1007520

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