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A Key Role for Subiculum-Fornix Connectivity in Recollection in Older Age

Individual differences in memory during aging are associated with the microstructure of the fornix, a bidirectional tract connecting the hippocampus with the diencephalon, basal forebrain and cortex. To investigate the origin of alterations in fornix microstructure, measurement of hippocampal subfie...

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Autores principales: Hartopp, Naomi, Wright, Paul, Ray, Nicola J., Evans, Tavia E., Metzler-Baddeley, Claudia, Aggleton, John P., O’Sullivan, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335321/
https://www.ncbi.nlm.nih.gov/pubmed/30687030
http://dx.doi.org/10.3389/fnsys.2018.00070
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author Hartopp, Naomi
Wright, Paul
Ray, Nicola J.
Evans, Tavia E.
Metzler-Baddeley, Claudia
Aggleton, John P.
O’Sullivan, Michael J.
author_facet Hartopp, Naomi
Wright, Paul
Ray, Nicola J.
Evans, Tavia E.
Metzler-Baddeley, Claudia
Aggleton, John P.
O’Sullivan, Michael J.
author_sort Hartopp, Naomi
collection PubMed
description Individual differences in memory during aging are associated with the microstructure of the fornix, a bidirectional tract connecting the hippocampus with the diencephalon, basal forebrain and cortex. To investigate the origin of alterations in fornix microstructure, measurement of hippocampal subfield volumes was combined with diffusion MRI and cognitive evaluation in a new sample of 31 healthy human participants aged 50–89 years. The fornix, uncinate and parahippocampal cingulum were reconstructed using diffusion MRI tractography. Episodic memory was assessed with free and cued verbal recall, visual recognition and paired associate learning tests. Recall performance was associated with fornix microstructure and hippocampal subfield volumes. Subiculum and CA1 volumes remained positively associated with fornix microstructure when controlling for other volumes. Subiculum volume was also associated with fornix microstructure independent of age. Regression analyses showed that subiculum-fornix associations explained more variation in recall than that of CA1-fornix associations. In a multivariable regression model, age and subiculum volume were independent predictors of free recall whilst fornix microstructure and CA1 volume were not. These results suggest that age-related changes in a network that includes the subiculum and fornix are important in cognitive change in healthy aging. These results match anatomical predictions concerning the importance of hippocampal – diencephalic projections for memory.
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spelling pubmed-63353212019-01-25 A Key Role for Subiculum-Fornix Connectivity in Recollection in Older Age Hartopp, Naomi Wright, Paul Ray, Nicola J. Evans, Tavia E. Metzler-Baddeley, Claudia Aggleton, John P. O’Sullivan, Michael J. Front Syst Neurosci Neuroscience Individual differences in memory during aging are associated with the microstructure of the fornix, a bidirectional tract connecting the hippocampus with the diencephalon, basal forebrain and cortex. To investigate the origin of alterations in fornix microstructure, measurement of hippocampal subfield volumes was combined with diffusion MRI and cognitive evaluation in a new sample of 31 healthy human participants aged 50–89 years. The fornix, uncinate and parahippocampal cingulum were reconstructed using diffusion MRI tractography. Episodic memory was assessed with free and cued verbal recall, visual recognition and paired associate learning tests. Recall performance was associated with fornix microstructure and hippocampal subfield volumes. Subiculum and CA1 volumes remained positively associated with fornix microstructure when controlling for other volumes. Subiculum volume was also associated with fornix microstructure independent of age. Regression analyses showed that subiculum-fornix associations explained more variation in recall than that of CA1-fornix associations. In a multivariable regression model, age and subiculum volume were independent predictors of free recall whilst fornix microstructure and CA1 volume were not. These results suggest that age-related changes in a network that includes the subiculum and fornix are important in cognitive change in healthy aging. These results match anatomical predictions concerning the importance of hippocampal – diencephalic projections for memory. Frontiers Media S.A. 2019-01-10 /pmc/articles/PMC6335321/ /pubmed/30687030 http://dx.doi.org/10.3389/fnsys.2018.00070 Text en Copyright © 2019 Hartopp, Wright, Ray, Evans, Metzler-Baddeley, Aggleton and O’Sullivan. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Hartopp, Naomi
Wright, Paul
Ray, Nicola J.
Evans, Tavia E.
Metzler-Baddeley, Claudia
Aggleton, John P.
O’Sullivan, Michael J.
A Key Role for Subiculum-Fornix Connectivity in Recollection in Older Age
title A Key Role for Subiculum-Fornix Connectivity in Recollection in Older Age
title_full A Key Role for Subiculum-Fornix Connectivity in Recollection in Older Age
title_fullStr A Key Role for Subiculum-Fornix Connectivity in Recollection in Older Age
title_full_unstemmed A Key Role for Subiculum-Fornix Connectivity in Recollection in Older Age
title_short A Key Role for Subiculum-Fornix Connectivity in Recollection in Older Age
title_sort key role for subiculum-fornix connectivity in recollection in older age
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335321/
https://www.ncbi.nlm.nih.gov/pubmed/30687030
http://dx.doi.org/10.3389/fnsys.2018.00070
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