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Endocrine Disrupting Chemicals Interfere With Leydig Cell Hormone Pathways During Testicular Descent in Idiopathic Cryptorchidism

Cryptorchidism, a frequent genital malformation in male newborn, remains in most cases idiopathic. On the basis of experimental, epidemiological, and clinical data, it has been included in the testicular dysgenesis syndrome and believed to be influenced, together with genetic and anatomic factors, b...

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Autores principales: Fénichel, Patrick, Chevalier, Nicolas, Lahlou, Najiba, Coquillard, Patrick, Wagner-Mahler, Kathy, Pugeat, Michel, Panaïa-Ferrari, Patricia, Brucker-Davis, Françoise
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335363/
https://www.ncbi.nlm.nih.gov/pubmed/30687232
http://dx.doi.org/10.3389/fendo.2018.00786
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author Fénichel, Patrick
Chevalier, Nicolas
Lahlou, Najiba
Coquillard, Patrick
Wagner-Mahler, Kathy
Pugeat, Michel
Panaïa-Ferrari, Patricia
Brucker-Davis, Françoise
author_facet Fénichel, Patrick
Chevalier, Nicolas
Lahlou, Najiba
Coquillard, Patrick
Wagner-Mahler, Kathy
Pugeat, Michel
Panaïa-Ferrari, Patricia
Brucker-Davis, Françoise
author_sort Fénichel, Patrick
collection PubMed
description Cryptorchidism, a frequent genital malformation in male newborn, remains in most cases idiopathic. On the basis of experimental, epidemiological, and clinical data, it has been included in the testicular dysgenesis syndrome and believed to be influenced, together with genetic and anatomic factors, by maternal exposure to endocrine disrupting chemicals (EDCs). Here, we analyze how EDCs may interfere with the control of testicular descent, which is regulated by two Leydig cell hormones, testosterone, and insulin like peptide 3 (INSL3).
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spelling pubmed-63353632019-01-25 Endocrine Disrupting Chemicals Interfere With Leydig Cell Hormone Pathways During Testicular Descent in Idiopathic Cryptorchidism Fénichel, Patrick Chevalier, Nicolas Lahlou, Najiba Coquillard, Patrick Wagner-Mahler, Kathy Pugeat, Michel Panaïa-Ferrari, Patricia Brucker-Davis, Françoise Front Endocrinol (Lausanne) Endocrinology Cryptorchidism, a frequent genital malformation in male newborn, remains in most cases idiopathic. On the basis of experimental, epidemiological, and clinical data, it has been included in the testicular dysgenesis syndrome and believed to be influenced, together with genetic and anatomic factors, by maternal exposure to endocrine disrupting chemicals (EDCs). Here, we analyze how EDCs may interfere with the control of testicular descent, which is regulated by two Leydig cell hormones, testosterone, and insulin like peptide 3 (INSL3). Frontiers Media S.A. 2019-01-10 /pmc/articles/PMC6335363/ /pubmed/30687232 http://dx.doi.org/10.3389/fendo.2018.00786 Text en Copyright © 2019 Fénichel, Chevalier, Lahlou, Coquillard, Wagner-Mahler, Pugeat, Panaïa-Ferrari and Brucker-Davis. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Fénichel, Patrick
Chevalier, Nicolas
Lahlou, Najiba
Coquillard, Patrick
Wagner-Mahler, Kathy
Pugeat, Michel
Panaïa-Ferrari, Patricia
Brucker-Davis, Françoise
Endocrine Disrupting Chemicals Interfere With Leydig Cell Hormone Pathways During Testicular Descent in Idiopathic Cryptorchidism
title Endocrine Disrupting Chemicals Interfere With Leydig Cell Hormone Pathways During Testicular Descent in Idiopathic Cryptorchidism
title_full Endocrine Disrupting Chemicals Interfere With Leydig Cell Hormone Pathways During Testicular Descent in Idiopathic Cryptorchidism
title_fullStr Endocrine Disrupting Chemicals Interfere With Leydig Cell Hormone Pathways During Testicular Descent in Idiopathic Cryptorchidism
title_full_unstemmed Endocrine Disrupting Chemicals Interfere With Leydig Cell Hormone Pathways During Testicular Descent in Idiopathic Cryptorchidism
title_short Endocrine Disrupting Chemicals Interfere With Leydig Cell Hormone Pathways During Testicular Descent in Idiopathic Cryptorchidism
title_sort endocrine disrupting chemicals interfere with leydig cell hormone pathways during testicular descent in idiopathic cryptorchidism
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335363/
https://www.ncbi.nlm.nih.gov/pubmed/30687232
http://dx.doi.org/10.3389/fendo.2018.00786
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