Early preclinical detection of prions in the skin of prion-infected animals

A definitive pre-mortem diagnosis of prion disease depends on brain biopsy for prion detection currently and no validated alternative preclinical diagnostic tests have been reported to date. To determine the feasibility of using skin for preclinical diagnosis, here we report ultrasensitive serial pr...

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Detalles Bibliográficos
Autores principales: Wang, Zerui, Manca, Matteo, Foutz, Aaron, Camacho, Manuel V., Raymond, Gregory J., Race, Brent, Orru, Christina D., Yuan, Jue, Shen, Pingping, Li, Baiya, Lang, Yue, Dang, Johnny, Adornato, Alise, Williams, Katie, Maurer, Nicholas R., Gambetti, Pierluigi, Xu, Bin, Surewicz, Witold, Petersen, Robert B., Dong, Xiaoping, Appleby, Brian S., Caughey, Byron, Cui, Li, Kong, Qingzhong, Zou, Wen-Quan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335425/
https://www.ncbi.nlm.nih.gov/pubmed/30651538
http://dx.doi.org/10.1038/s41467-018-08130-9

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