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Efficacy of topical application of standardized extract of Tragopogon graminifolius in the healing process of experimental burn wounds
Tragopogon graminifolius DC. is a perennial plant from the family Asteraceae which grows in West parts of Iran. Several biological activities like antimicrobial, antioxidant and anti-inflammatory effects are reported for the plant. The aim of this study was to assess the wound healing activity of st...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335475/ https://www.ncbi.nlm.nih.gov/pubmed/30671366 http://dx.doi.org/10.1016/j.jtcme.2018.02.002 |
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author | Heidari, Mohammad Bahramsoltani, Roodabeh Abdolghaffari, Amir Hossein Rahimi, Roja Esfandyari, Mohammadamin Baeeri, Maryam Hassanzadeh, Gholamreza Abdollahi, Mohammad Farzaei, Mohammad Hosein |
author_facet | Heidari, Mohammad Bahramsoltani, Roodabeh Abdolghaffari, Amir Hossein Rahimi, Roja Esfandyari, Mohammadamin Baeeri, Maryam Hassanzadeh, Gholamreza Abdollahi, Mohammad Farzaei, Mohammad Hosein |
author_sort | Heidari, Mohammad |
collection | PubMed |
description | Tragopogon graminifolius DC. is a perennial plant from the family Asteraceae which grows in West parts of Iran. Several biological activities like antimicrobial, antioxidant and anti-inflammatory effects are reported for the plant. The aim of this study was to assess the wound healing activity of standardized extract from T. graminifolius (TG) aerial parts. Topical standardized TG extract with 5% and 10% concentrations in eucerine base was assessed for its healing properties on second degree burn in rats during a 14-day period. Biomarkers of oxidative damage including total antioxidant power, lipid peroxidation and total thiol molecules of the skin tissue samples were also evaluated. Results showed that 10%TG had the best efficacy with 80 ± 3% wound closure and tissue repair in comparison to negative control (p < 0.05). Significant reduction of tissue oxidative stress biomarkers was also observed. Histological analyses confirmed wound healing activity of TG extract, as well. Considering the antioxidative stress and anti-inflammatory activities of TG, explained by the high content of phenolic compounds of the plant, standardized TG extract could be considered as a natural remedy for the treatment of burn wounds. Further clinical studies are suggested to confirm the effectiveness of TG as a wound healing agent. |
format | Online Article Text |
id | pubmed-6335475 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-63354752019-01-22 Efficacy of topical application of standardized extract of Tragopogon graminifolius in the healing process of experimental burn wounds Heidari, Mohammad Bahramsoltani, Roodabeh Abdolghaffari, Amir Hossein Rahimi, Roja Esfandyari, Mohammadamin Baeeri, Maryam Hassanzadeh, Gholamreza Abdollahi, Mohammad Farzaei, Mohammad Hosein J Tradit Complement Med Original Article Tragopogon graminifolius DC. is a perennial plant from the family Asteraceae which grows in West parts of Iran. Several biological activities like antimicrobial, antioxidant and anti-inflammatory effects are reported for the plant. The aim of this study was to assess the wound healing activity of standardized extract from T. graminifolius (TG) aerial parts. Topical standardized TG extract with 5% and 10% concentrations in eucerine base was assessed for its healing properties on second degree burn in rats during a 14-day period. Biomarkers of oxidative damage including total antioxidant power, lipid peroxidation and total thiol molecules of the skin tissue samples were also evaluated. Results showed that 10%TG had the best efficacy with 80 ± 3% wound closure and tissue repair in comparison to negative control (p < 0.05). Significant reduction of tissue oxidative stress biomarkers was also observed. Histological analyses confirmed wound healing activity of TG extract, as well. Considering the antioxidative stress and anti-inflammatory activities of TG, explained by the high content of phenolic compounds of the plant, standardized TG extract could be considered as a natural remedy for the treatment of burn wounds. Further clinical studies are suggested to confirm the effectiveness of TG as a wound healing agent. Elsevier 2018-04-27 /pmc/articles/PMC6335475/ /pubmed/30671366 http://dx.doi.org/10.1016/j.jtcme.2018.02.002 Text en © 2018 Center for Food and Biomolecules, National Taiwan University. Production and hosting by Elsevier Taiwan LLC. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Article Heidari, Mohammad Bahramsoltani, Roodabeh Abdolghaffari, Amir Hossein Rahimi, Roja Esfandyari, Mohammadamin Baeeri, Maryam Hassanzadeh, Gholamreza Abdollahi, Mohammad Farzaei, Mohammad Hosein Efficacy of topical application of standardized extract of Tragopogon graminifolius in the healing process of experimental burn wounds |
title | Efficacy of topical application of standardized extract of Tragopogon graminifolius in the healing process of experimental burn wounds |
title_full | Efficacy of topical application of standardized extract of Tragopogon graminifolius in the healing process of experimental burn wounds |
title_fullStr | Efficacy of topical application of standardized extract of Tragopogon graminifolius in the healing process of experimental burn wounds |
title_full_unstemmed | Efficacy of topical application of standardized extract of Tragopogon graminifolius in the healing process of experimental burn wounds |
title_short | Efficacy of topical application of standardized extract of Tragopogon graminifolius in the healing process of experimental burn wounds |
title_sort | efficacy of topical application of standardized extract of tragopogon graminifolius in the healing process of experimental burn wounds |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335475/ https://www.ncbi.nlm.nih.gov/pubmed/30671366 http://dx.doi.org/10.1016/j.jtcme.2018.02.002 |
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