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Efficacy of topical application of standardized extract of Tragopogon graminifolius in the healing process of experimental burn wounds

Tragopogon graminifolius DC. is a perennial plant from the family Asteraceae which grows in West parts of Iran. Several biological activities like antimicrobial, antioxidant and anti-inflammatory effects are reported for the plant. The aim of this study was to assess the wound healing activity of st...

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Autores principales: Heidari, Mohammad, Bahramsoltani, Roodabeh, Abdolghaffari, Amir Hossein, Rahimi, Roja, Esfandyari, Mohammadamin, Baeeri, Maryam, Hassanzadeh, Gholamreza, Abdollahi, Mohammad, Farzaei, Mohammad Hosein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335475/
https://www.ncbi.nlm.nih.gov/pubmed/30671366
http://dx.doi.org/10.1016/j.jtcme.2018.02.002
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author Heidari, Mohammad
Bahramsoltani, Roodabeh
Abdolghaffari, Amir Hossein
Rahimi, Roja
Esfandyari, Mohammadamin
Baeeri, Maryam
Hassanzadeh, Gholamreza
Abdollahi, Mohammad
Farzaei, Mohammad Hosein
author_facet Heidari, Mohammad
Bahramsoltani, Roodabeh
Abdolghaffari, Amir Hossein
Rahimi, Roja
Esfandyari, Mohammadamin
Baeeri, Maryam
Hassanzadeh, Gholamreza
Abdollahi, Mohammad
Farzaei, Mohammad Hosein
author_sort Heidari, Mohammad
collection PubMed
description Tragopogon graminifolius DC. is a perennial plant from the family Asteraceae which grows in West parts of Iran. Several biological activities like antimicrobial, antioxidant and anti-inflammatory effects are reported for the plant. The aim of this study was to assess the wound healing activity of standardized extract from T. graminifolius (TG) aerial parts. Topical standardized TG extract with 5% and 10% concentrations in eucerine base was assessed for its healing properties on second degree burn in rats during a 14-day period. Biomarkers of oxidative damage including total antioxidant power, lipid peroxidation and total thiol molecules of the skin tissue samples were also evaluated. Results showed that 10%TG had the best efficacy with 80 ± 3% wound closure and tissue repair in comparison to negative control (p < 0.05). Significant reduction of tissue oxidative stress biomarkers was also observed. Histological analyses confirmed wound healing activity of TG extract, as well. Considering the antioxidative stress and anti-inflammatory activities of TG, explained by the high content of phenolic compounds of the plant, standardized TG extract could be considered as a natural remedy for the treatment of burn wounds. Further clinical studies are suggested to confirm the effectiveness of TG as a wound healing agent.
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spelling pubmed-63354752019-01-22 Efficacy of topical application of standardized extract of Tragopogon graminifolius in the healing process of experimental burn wounds Heidari, Mohammad Bahramsoltani, Roodabeh Abdolghaffari, Amir Hossein Rahimi, Roja Esfandyari, Mohammadamin Baeeri, Maryam Hassanzadeh, Gholamreza Abdollahi, Mohammad Farzaei, Mohammad Hosein J Tradit Complement Med Original Article Tragopogon graminifolius DC. is a perennial plant from the family Asteraceae which grows in West parts of Iran. Several biological activities like antimicrobial, antioxidant and anti-inflammatory effects are reported for the plant. The aim of this study was to assess the wound healing activity of standardized extract from T. graminifolius (TG) aerial parts. Topical standardized TG extract with 5% and 10% concentrations in eucerine base was assessed for its healing properties on second degree burn in rats during a 14-day period. Biomarkers of oxidative damage including total antioxidant power, lipid peroxidation and total thiol molecules of the skin tissue samples were also evaluated. Results showed that 10%TG had the best efficacy with 80 ± 3% wound closure and tissue repair in comparison to negative control (p < 0.05). Significant reduction of tissue oxidative stress biomarkers was also observed. Histological analyses confirmed wound healing activity of TG extract, as well. Considering the antioxidative stress and anti-inflammatory activities of TG, explained by the high content of phenolic compounds of the plant, standardized TG extract could be considered as a natural remedy for the treatment of burn wounds. Further clinical studies are suggested to confirm the effectiveness of TG as a wound healing agent. Elsevier 2018-04-27 /pmc/articles/PMC6335475/ /pubmed/30671366 http://dx.doi.org/10.1016/j.jtcme.2018.02.002 Text en © 2018 Center for Food and Biomolecules, National Taiwan University. Production and hosting by Elsevier Taiwan LLC. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Heidari, Mohammad
Bahramsoltani, Roodabeh
Abdolghaffari, Amir Hossein
Rahimi, Roja
Esfandyari, Mohammadamin
Baeeri, Maryam
Hassanzadeh, Gholamreza
Abdollahi, Mohammad
Farzaei, Mohammad Hosein
Efficacy of topical application of standardized extract of Tragopogon graminifolius in the healing process of experimental burn wounds
title Efficacy of topical application of standardized extract of Tragopogon graminifolius in the healing process of experimental burn wounds
title_full Efficacy of topical application of standardized extract of Tragopogon graminifolius in the healing process of experimental burn wounds
title_fullStr Efficacy of topical application of standardized extract of Tragopogon graminifolius in the healing process of experimental burn wounds
title_full_unstemmed Efficacy of topical application of standardized extract of Tragopogon graminifolius in the healing process of experimental burn wounds
title_short Efficacy of topical application of standardized extract of Tragopogon graminifolius in the healing process of experimental burn wounds
title_sort efficacy of topical application of standardized extract of tragopogon graminifolius in the healing process of experimental burn wounds
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335475/
https://www.ncbi.nlm.nih.gov/pubmed/30671366
http://dx.doi.org/10.1016/j.jtcme.2018.02.002
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