Inhibition of the STAT5/Pim Kinase Axis Enhances Cytotoxic Effects of Proteasome Inhibitors on FLT3-ITD–Positive AML Cells by Cooperatively Inhibiting the mTORC1/4EBP1/S6K/Mcl-1 Pathway()

FLT3-ITD and FLT3-TKD are the most frequent tyrosine kinase mutations in acute myeloid leukemia (AML), with the former conferring a poor prognosis. We have recently revealed that FLT3-ITD confers resistance to the PI3K/AKT pathway inhibitors by protecting the mTORC1/4EBP1/Mcl-1 pathway through Pim k...

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Detalles Bibliográficos
Autores principales: Nogami, Ayako, Okada, Keigo, Ishida, Shinya, Akiyama, Hiroki, Umezawa, Yoshihiro, Miura, Osamu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2018
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335494/
https://www.ncbi.nlm.nih.gov/pubmed/30472492
http://dx.doi.org/10.1016/j.tranon.2018.11.001

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