Vaccine-Induced Protection from Homologous Tier 2 SHIV Challenge in Nonhuman Primates Depends on Serum-Neutralizing Antibody Titers

Passive administration of HIV neutralizing antibodies (nAbs) can protect macaques from hard-to-neutralize (tier 2) chimeric simian-human immunodeficiency virus (SHIV) challenge. However, conditions for nAb-mediated protection after vaccination have not been established. Here, we selected groups of 6...

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Detalles Bibliográficos
Autores principales: Pauthner, Matthias G., Nkolola, Joseph P., Havenar-Daughton, Colin, Murrell, Ben, Reiss, Samantha M., Bastidas, Raiza, Prévost, Jérémie, Nedellec, Rebecca, von Bredow, Benjamin, Abbink, Peter, Cottrell, Christopher A., Kulp, Daniel W., Tokatlian, Talar, Nogal, Bartek, Bianchi, Matteo, Li, Hui, Lee, Jeong Hyun, Butera, Salvatore T., Evans, David T., Hangartner, Lars, Finzi, Andrés, Wilson, Ian A., Wyatt, Richard T., Irvine, Darrell J., Schief, William R., Ward, Andrew B., Sanders, Rogier W., Crotty, Shane, Shaw, George M., Barouch, Dan H., Burton, Dennis R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335502/
https://www.ncbi.nlm.nih.gov/pubmed/30552025
http://dx.doi.org/10.1016/j.immuni.2018.11.011

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