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Role of deformable image registration for delivered dose accumulation of adaptive external beam radiation therapy and brachytherapy in cervical cancer

PURPOSE: Deformable image registration (DIR) can be used to accumulate the absorbed dose distribution of daily image-guided adaptive external beam radiation treatment (EBRT) and brachytherapy (BT). Since dose-volume parameter addition assumes a uniform delivered EBRT dose around the planned BT boost...

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Autores principales: van Heerden, Laura E, Visser, Jorrit, Koedooder, Kees, Rasch, Coen RN, Pieters, Bradley R, Bel, Arjan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335550/
https://www.ncbi.nlm.nih.gov/pubmed/30662477
http://dx.doi.org/10.5114/jcb.2018.79840
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author van Heerden, Laura E
Visser, Jorrit
Koedooder, Kees
Rasch, Coen RN
Pieters, Bradley R
Bel, Arjan
author_facet van Heerden, Laura E
Visser, Jorrit
Koedooder, Kees
Rasch, Coen RN
Pieters, Bradley R
Bel, Arjan
author_sort van Heerden, Laura E
collection PubMed
description PURPOSE: Deformable image registration (DIR) can be used to accumulate the absorbed dose distribution of daily image-guided adaptive external beam radiation treatment (EBRT) and brachytherapy (BT). Since dose-volume parameter addition assumes a uniform delivered EBRT dose around the planned BT boost, the added value of DIR over direct addition was investigated for dose accumulation in bladder and rectum. MATERIAL AND METHODS: For 10 patients (EBRT 46/46.2 Gy(EQD2), EBRT + BT: D(90) 85-90 Gy(EQD2), in equivalent dose in 2 Gy fractions), the actually delivered dose from adaptive volumetric-modulated arc therapy (VMAT)/intensity-modulated radiotherapy (IMRT) EBRT was calculated using the daily anatomy from the cone-beam computed tomography (CBCT) scans acquired prior to irradiation. The CBCT of the first EBRT fraction and the BT planning MRI were registered using DIR. The cumulative dose to the 2 cm(3) with the highest dose (D(2cm3)) from EBRT and BT to the bladder and rectum was calculated and compared to direct addition assuming a uniform EBRT dose (UD). RESULTS: Differences (DIR-UD) in the total EBRT + BT dose ranged between –0.2-3.9 Gy(EQD2) (bladder) and –1.0-3.7 Gy(EQD2) (rectum). The total EBRT + BT dose calculated with DIR was at most 104% of the dose calculated with the UD method. CONCLUSIONS: Differences between UD and DIR were small (< 3.9 Gy(EQD2)). The dose delivered with adaptive VMAT/IMRT EBRT to bladder and rectum near the planned BT boost can be considered uniform for the evaluation of bladder/rectum D(2cm3).
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spelling pubmed-63355502019-01-18 Role of deformable image registration for delivered dose accumulation of adaptive external beam radiation therapy and brachytherapy in cervical cancer van Heerden, Laura E Visser, Jorrit Koedooder, Kees Rasch, Coen RN Pieters, Bradley R Bel, Arjan J Contemp Brachytherapy Original Paper PURPOSE: Deformable image registration (DIR) can be used to accumulate the absorbed dose distribution of daily image-guided adaptive external beam radiation treatment (EBRT) and brachytherapy (BT). Since dose-volume parameter addition assumes a uniform delivered EBRT dose around the planned BT boost, the added value of DIR over direct addition was investigated for dose accumulation in bladder and rectum. MATERIAL AND METHODS: For 10 patients (EBRT 46/46.2 Gy(EQD2), EBRT + BT: D(90) 85-90 Gy(EQD2), in equivalent dose in 2 Gy fractions), the actually delivered dose from adaptive volumetric-modulated arc therapy (VMAT)/intensity-modulated radiotherapy (IMRT) EBRT was calculated using the daily anatomy from the cone-beam computed tomography (CBCT) scans acquired prior to irradiation. The CBCT of the first EBRT fraction and the BT planning MRI were registered using DIR. The cumulative dose to the 2 cm(3) with the highest dose (D(2cm3)) from EBRT and BT to the bladder and rectum was calculated and compared to direct addition assuming a uniform EBRT dose (UD). RESULTS: Differences (DIR-UD) in the total EBRT + BT dose ranged between –0.2-3.9 Gy(EQD2) (bladder) and –1.0-3.7 Gy(EQD2) (rectum). The total EBRT + BT dose calculated with DIR was at most 104% of the dose calculated with the UD method. CONCLUSIONS: Differences between UD and DIR were small (< 3.9 Gy(EQD2)). The dose delivered with adaptive VMAT/IMRT EBRT to bladder and rectum near the planned BT boost can be considered uniform for the evaluation of bladder/rectum D(2cm3). Termedia Publishing House 2018-12-28 2018-12 /pmc/articles/PMC6335550/ /pubmed/30662477 http://dx.doi.org/10.5114/jcb.2018.79840 Text en Copyright: © 2018 Termedia Sp. z o. o. http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Original Paper
van Heerden, Laura E
Visser, Jorrit
Koedooder, Kees
Rasch, Coen RN
Pieters, Bradley R
Bel, Arjan
Role of deformable image registration for delivered dose accumulation of adaptive external beam radiation therapy and brachytherapy in cervical cancer
title Role of deformable image registration for delivered dose accumulation of adaptive external beam radiation therapy and brachytherapy in cervical cancer
title_full Role of deformable image registration for delivered dose accumulation of adaptive external beam radiation therapy and brachytherapy in cervical cancer
title_fullStr Role of deformable image registration for delivered dose accumulation of adaptive external beam radiation therapy and brachytherapy in cervical cancer
title_full_unstemmed Role of deformable image registration for delivered dose accumulation of adaptive external beam radiation therapy and brachytherapy in cervical cancer
title_short Role of deformable image registration for delivered dose accumulation of adaptive external beam radiation therapy and brachytherapy in cervical cancer
title_sort role of deformable image registration for delivered dose accumulation of adaptive external beam radiation therapy and brachytherapy in cervical cancer
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335550/
https://www.ncbi.nlm.nih.gov/pubmed/30662477
http://dx.doi.org/10.5114/jcb.2018.79840
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