Neuron-Glia Interactions Increase Neuronal Phenotypes in Tuberous Sclerosis Complex Patient iPSC-Derived Models

Tuberous sclerosis complex (TSC) is a rare neurodevelopmental disorder resulting from autosomal dominant mutations in the TSC1 or TSC2 genes, leading to a hyperactivated mammalian target of rapamycin (mTOR) pathway, and gray and white matter defects in the brain. To study the involvement of neuron-g...

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Detalles Bibliográficos
Autores principales: G. Nadadhur, Aishwarya, Alsaqati, Mouhamed, Gasparotto, Lisa, Cornelissen-Steijger, Paulien, van Hugte, Eline, Dooves, Stephanie, Harwood, Adrian J., Heine, Vivi M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335594/
https://www.ncbi.nlm.nih.gov/pubmed/30581017
http://dx.doi.org/10.1016/j.stemcr.2018.11.019

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