Neurite Collapse and Altered ER Ca(2+) Control in Human Parkinson Disease Patient iPSC-Derived Neurons with LRRK2 G2019S Mutation

The Parkinson disease (PD) genetic LRRK2 gain-of-function mutations may relate to the ER pathological changes seen in PD patients at postmortem. Human induced pluripotent stem cell (iPSC)-derived neurons with the PD pathogenic LRRK2 G2019S mutation exhibited neurite collapse when challenged with the...

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Detalles Bibliográficos
Autores principales: Korecka, Joanna A., Talbot, Sebastien, Osborn, Teresia M., de Leeuw, Sherida M., Levy, Simon A., Ferrari, Eliza J., Moskites, Alyssa, Atkinson, Elise, Jodelka, Francine M., Hinrich, Anthony J., Hastings, Michelle L., Woolf, Clifford J., Hallett, Penelope J., Isacson, Ole
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335600/
https://www.ncbi.nlm.nih.gov/pubmed/30595548
http://dx.doi.org/10.1016/j.stemcr.2018.11.021

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