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The JNK signaling pathway plays a key role in methuosis (non-apoptotic cell death) induced by MOMIPP in glioblastoma

BACKGROUND: Synthetic indolyl- pyridinyl- propenones (IPPs) induce methuosis, a form of non-apoptotic cell death, in glioblastoma and other cancer cell lines. Methuosis is characterized by accumulation of cytoplasmic vacuoles derived from macropinosomes and late endosomes, followed by metabolic fail...

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Detalles Bibliográficos
Autores principales:	Li, Zehui, Mbah, Nneka E., Overmeyer, Jean H., Sarver, Jeffrey G., George, Sage, Trabbic, Christopher J., Erhardt, Paul W., Maltese, William A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335761/ https://www.ncbi.nlm.nih.gov/pubmed/30651087 http://dx.doi.org/10.1186/s12885-019-5288-y

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