Demethylation by low-dose 5-aza-2′-deoxycytidine impairs 3D melanoma invasion partially through miR-199a-3p expression revealing the role of this miR in melanoma

BACKGROUND: Efficient treatments against metastatic melanoma dissemination are still lacking. Here, we report that low-cytotoxic concentrations of 5-aza-2′-deoxycytidine, a DNA demethylating agent, prevent in vitro 3D invasiveness of metastatic melanoma cells and reduce lung metastasis formation in...

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Detalles Bibliográficos
Autores principales: Desjobert, Cécile, Carrier, Arnaud, Delmas, Audrey, Marzese, Diego M., Daunay, Antoine, Busato, Florence, Pillon, Arnaud, Tost, Jörg, Riond, Joëlle, Favre, Gilles, Etievant, Chantal, Arimondo, Paola B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335767/
https://www.ncbi.nlm.nih.gov/pubmed/30651148
http://dx.doi.org/10.1186/s13148-018-0600-2

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