Memantine potentiates cytarabine-induced cell death of acute leukemia correlating with inhibition of K(v)1.3 potassium channels, AKT and ERK1/2 signaling

BACKGROUND: Treatment of acute leukemia is challenging and long-lasting remissions are difficult to induce. Innovative therapy approaches aim to complement standard chemotherapy to improve drug efficacy and decrease toxicity. Promising new therapeutic targets in cancer therapy include voltage-gated...

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Detalles Bibliográficos
Autores principales: Lowinus, Theresa, Heidel, Florian H., Bose, Tanima, Nimmagadda, Subbaiah Chary, Schnöder, Tina, Cammann, Clemens, Schmitz, Ingo, Seifert, Ulrike, Fischer, Thomas, Schraven, Burkhart, Bommhardt, Ursula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335768/
https://www.ncbi.nlm.nih.gov/pubmed/30651113
http://dx.doi.org/10.1186/s12964-018-0317-z

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