Cargando…

Time to minimal disease activity in relation to quality of life, productivity, and radiographic damage 1 year after diagnosis in psoriatic arthritis

BACKGROUND: In a cohort of patients with newly diagnosed psoriatic arthritis (PsA) who received usual care, we investigated the impact of time elapsed to minimal disease activity (MDA) on health-related quality of life (HRQoL), work productivity, and radiographic damage throughout the first year aft...

Descripción completa

Detalles Bibliográficos
Autores principales: Wervers, Kim, Luime, Jolanda J., Tchetverikov, Ilja, Gerards, Andreas H., Kok, Marc R., Appels, Cathelijne W. Y., van der Graaff, Wiebo L., van Groenendael, Johannes H. L. M., Korswagen, Lindy-Anne, Veris-van Dieren, Josien J., Hazes, Johanna M. W., Vis, Marijn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335829/
https://www.ncbi.nlm.nih.gov/pubmed/30651121
http://dx.doi.org/10.1186/s13075-019-1811-4
_version_ 1783387967929188352
author Wervers, Kim
Luime, Jolanda J.
Tchetverikov, Ilja
Gerards, Andreas H.
Kok, Marc R.
Appels, Cathelijne W. Y.
van der Graaff, Wiebo L.
van Groenendael, Johannes H. L. M.
Korswagen, Lindy-Anne
Veris-van Dieren, Josien J.
Hazes, Johanna M. W.
Vis, Marijn
author_facet Wervers, Kim
Luime, Jolanda J.
Tchetverikov, Ilja
Gerards, Andreas H.
Kok, Marc R.
Appels, Cathelijne W. Y.
van der Graaff, Wiebo L.
van Groenendael, Johannes H. L. M.
Korswagen, Lindy-Anne
Veris-van Dieren, Josien J.
Hazes, Johanna M. W.
Vis, Marijn
author_sort Wervers, Kim
collection PubMed
description BACKGROUND: In a cohort of patients with newly diagnosed psoriatic arthritis (PsA) who received usual care, we investigated the impact of time elapsed to minimal disease activity (MDA) on health-related quality of life (HRQoL), work productivity, and radiographic damage throughout the first year after diagnosis. METHODS: Data collected in the Dutch southwest early PsA cohort (DEPAR) study were analyzed. These three-monthly data encompassed disease activity, HRQOL was measured with the Short Form 36 (SF36) Physical Component Scale (SF36-PCS) and Mental Component Scale, and productivity was measured with the Productivity Cost Questionnaire. Radiographic damage was scored at baseline and at 12 months with the PsA-modified Sharp/van der Heijde score. Patients were classified by time to MDA as in early (within 3 months), late (at 6–12 months), and never MDA in the first year. RESULTS: We included 296 patients who had had their 1-year outpatient visit (mean age 51 years, 53% male). Ninety-six (32%) were classified as early MDA, 78 (26%) as late MDA, and 98 (33%) as never MDA. Data of 24 patients (8%) were missing. SF36-PCS and productivity scores improved after gaining MDA, but remained low in never MDA patients. At 1 year, SF36-PCS and productivity scores were similar in early and late MDA patients. Radiographic progression rate was low and similar in all groups. CONCLUSION: Gaining MDA was associated with considerable improvement in HRQoL and functioning, irrespective of time to first MDA. In the one third of patients not in MDA in the first year, the disease had a substantial health impact.
format Online
Article
Text
id pubmed-6335829
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-63358292019-01-23 Time to minimal disease activity in relation to quality of life, productivity, and radiographic damage 1 year after diagnosis in psoriatic arthritis Wervers, Kim Luime, Jolanda J. Tchetverikov, Ilja Gerards, Andreas H. Kok, Marc R. Appels, Cathelijne W. Y. van der Graaff, Wiebo L. van Groenendael, Johannes H. L. M. Korswagen, Lindy-Anne Veris-van Dieren, Josien J. Hazes, Johanna M. W. Vis, Marijn Arthritis Res Ther Research Article BACKGROUND: In a cohort of patients with newly diagnosed psoriatic arthritis (PsA) who received usual care, we investigated the impact of time elapsed to minimal disease activity (MDA) on health-related quality of life (HRQoL), work productivity, and radiographic damage throughout the first year after diagnosis. METHODS: Data collected in the Dutch southwest early PsA cohort (DEPAR) study were analyzed. These three-monthly data encompassed disease activity, HRQOL was measured with the Short Form 36 (SF36) Physical Component Scale (SF36-PCS) and Mental Component Scale, and productivity was measured with the Productivity Cost Questionnaire. Radiographic damage was scored at baseline and at 12 months with the PsA-modified Sharp/van der Heijde score. Patients were classified by time to MDA as in early (within 3 months), late (at 6–12 months), and never MDA in the first year. RESULTS: We included 296 patients who had had their 1-year outpatient visit (mean age 51 years, 53% male). Ninety-six (32%) were classified as early MDA, 78 (26%) as late MDA, and 98 (33%) as never MDA. Data of 24 patients (8%) were missing. SF36-PCS and productivity scores improved after gaining MDA, but remained low in never MDA patients. At 1 year, SF36-PCS and productivity scores were similar in early and late MDA patients. Radiographic progression rate was low and similar in all groups. CONCLUSION: Gaining MDA was associated with considerable improvement in HRQoL and functioning, irrespective of time to first MDA. In the one third of patients not in MDA in the first year, the disease had a substantial health impact. BioMed Central 2019-01-16 2019 /pmc/articles/PMC6335829/ /pubmed/30651121 http://dx.doi.org/10.1186/s13075-019-1811-4 Text en © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Wervers, Kim
Luime, Jolanda J.
Tchetverikov, Ilja
Gerards, Andreas H.
Kok, Marc R.
Appels, Cathelijne W. Y.
van der Graaff, Wiebo L.
van Groenendael, Johannes H. L. M.
Korswagen, Lindy-Anne
Veris-van Dieren, Josien J.
Hazes, Johanna M. W.
Vis, Marijn
Time to minimal disease activity in relation to quality of life, productivity, and radiographic damage 1 year after diagnosis in psoriatic arthritis
title Time to minimal disease activity in relation to quality of life, productivity, and radiographic damage 1 year after diagnosis in psoriatic arthritis
title_full Time to minimal disease activity in relation to quality of life, productivity, and radiographic damage 1 year after diagnosis in psoriatic arthritis
title_fullStr Time to minimal disease activity in relation to quality of life, productivity, and radiographic damage 1 year after diagnosis in psoriatic arthritis
title_full_unstemmed Time to minimal disease activity in relation to quality of life, productivity, and radiographic damage 1 year after diagnosis in psoriatic arthritis
title_short Time to minimal disease activity in relation to quality of life, productivity, and radiographic damage 1 year after diagnosis in psoriatic arthritis
title_sort time to minimal disease activity in relation to quality of life, productivity, and radiographic damage 1 year after diagnosis in psoriatic arthritis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335829/
https://www.ncbi.nlm.nih.gov/pubmed/30651121
http://dx.doi.org/10.1186/s13075-019-1811-4
work_keys_str_mv AT werverskim timetominimaldiseaseactivityinrelationtoqualityoflifeproductivityandradiographicdamage1yearafterdiagnosisinpsoriaticarthritis
AT luimejolandaj timetominimaldiseaseactivityinrelationtoqualityoflifeproductivityandradiographicdamage1yearafterdiagnosisinpsoriaticarthritis
AT tchetverikovilja timetominimaldiseaseactivityinrelationtoqualityoflifeproductivityandradiographicdamage1yearafterdiagnosisinpsoriaticarthritis
AT gerardsandreash timetominimaldiseaseactivityinrelationtoqualityoflifeproductivityandradiographicdamage1yearafterdiagnosisinpsoriaticarthritis
AT kokmarcr timetominimaldiseaseactivityinrelationtoqualityoflifeproductivityandradiographicdamage1yearafterdiagnosisinpsoriaticarthritis
AT appelscathelijnewy timetominimaldiseaseactivityinrelationtoqualityoflifeproductivityandradiographicdamage1yearafterdiagnosisinpsoriaticarthritis
AT vandergraaffwiebol timetominimaldiseaseactivityinrelationtoqualityoflifeproductivityandradiographicdamage1yearafterdiagnosisinpsoriaticarthritis
AT vangroenendaeljohanneshlm timetominimaldiseaseactivityinrelationtoqualityoflifeproductivityandradiographicdamage1yearafterdiagnosisinpsoriaticarthritis
AT korswagenlindyanne timetominimaldiseaseactivityinrelationtoqualityoflifeproductivityandradiographicdamage1yearafterdiagnosisinpsoriaticarthritis
AT verisvandierenjosienj timetominimaldiseaseactivityinrelationtoqualityoflifeproductivityandradiographicdamage1yearafterdiagnosisinpsoriaticarthritis
AT hazesjohannamw timetominimaldiseaseactivityinrelationtoqualityoflifeproductivityandradiographicdamage1yearafterdiagnosisinpsoriaticarthritis
AT vismarijn timetominimaldiseaseactivityinrelationtoqualityoflifeproductivityandradiographicdamage1yearafterdiagnosisinpsoriaticarthritis
AT timetominimaldiseaseactivityinrelationtoqualityoflifeproductivityandradiographicdamage1yearafterdiagnosisinpsoriaticarthritis