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Time to minimal disease activity in relation to quality of life, productivity, and radiographic damage 1 year after diagnosis in psoriatic arthritis
BACKGROUND: In a cohort of patients with newly diagnosed psoriatic arthritis (PsA) who received usual care, we investigated the impact of time elapsed to minimal disease activity (MDA) on health-related quality of life (HRQoL), work productivity, and radiographic damage throughout the first year aft...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335829/ https://www.ncbi.nlm.nih.gov/pubmed/30651121 http://dx.doi.org/10.1186/s13075-019-1811-4 |
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author | Wervers, Kim Luime, Jolanda J. Tchetverikov, Ilja Gerards, Andreas H. Kok, Marc R. Appels, Cathelijne W. Y. van der Graaff, Wiebo L. van Groenendael, Johannes H. L. M. Korswagen, Lindy-Anne Veris-van Dieren, Josien J. Hazes, Johanna M. W. Vis, Marijn |
author_facet | Wervers, Kim Luime, Jolanda J. Tchetverikov, Ilja Gerards, Andreas H. Kok, Marc R. Appels, Cathelijne W. Y. van der Graaff, Wiebo L. van Groenendael, Johannes H. L. M. Korswagen, Lindy-Anne Veris-van Dieren, Josien J. Hazes, Johanna M. W. Vis, Marijn |
author_sort | Wervers, Kim |
collection | PubMed |
description | BACKGROUND: In a cohort of patients with newly diagnosed psoriatic arthritis (PsA) who received usual care, we investigated the impact of time elapsed to minimal disease activity (MDA) on health-related quality of life (HRQoL), work productivity, and radiographic damage throughout the first year after diagnosis. METHODS: Data collected in the Dutch southwest early PsA cohort (DEPAR) study were analyzed. These three-monthly data encompassed disease activity, HRQOL was measured with the Short Form 36 (SF36) Physical Component Scale (SF36-PCS) and Mental Component Scale, and productivity was measured with the Productivity Cost Questionnaire. Radiographic damage was scored at baseline and at 12 months with the PsA-modified Sharp/van der Heijde score. Patients were classified by time to MDA as in early (within 3 months), late (at 6–12 months), and never MDA in the first year. RESULTS: We included 296 patients who had had their 1-year outpatient visit (mean age 51 years, 53% male). Ninety-six (32%) were classified as early MDA, 78 (26%) as late MDA, and 98 (33%) as never MDA. Data of 24 patients (8%) were missing. SF36-PCS and productivity scores improved after gaining MDA, but remained low in never MDA patients. At 1 year, SF36-PCS and productivity scores were similar in early and late MDA patients. Radiographic progression rate was low and similar in all groups. CONCLUSION: Gaining MDA was associated with considerable improvement in HRQoL and functioning, irrespective of time to first MDA. In the one third of patients not in MDA in the first year, the disease had a substantial health impact. |
format | Online Article Text |
id | pubmed-6335829 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-63358292019-01-23 Time to minimal disease activity in relation to quality of life, productivity, and radiographic damage 1 year after diagnosis in psoriatic arthritis Wervers, Kim Luime, Jolanda J. Tchetverikov, Ilja Gerards, Andreas H. Kok, Marc R. Appels, Cathelijne W. Y. van der Graaff, Wiebo L. van Groenendael, Johannes H. L. M. Korswagen, Lindy-Anne Veris-van Dieren, Josien J. Hazes, Johanna M. W. Vis, Marijn Arthritis Res Ther Research Article BACKGROUND: In a cohort of patients with newly diagnosed psoriatic arthritis (PsA) who received usual care, we investigated the impact of time elapsed to minimal disease activity (MDA) on health-related quality of life (HRQoL), work productivity, and radiographic damage throughout the first year after diagnosis. METHODS: Data collected in the Dutch southwest early PsA cohort (DEPAR) study were analyzed. These three-monthly data encompassed disease activity, HRQOL was measured with the Short Form 36 (SF36) Physical Component Scale (SF36-PCS) and Mental Component Scale, and productivity was measured with the Productivity Cost Questionnaire. Radiographic damage was scored at baseline and at 12 months with the PsA-modified Sharp/van der Heijde score. Patients were classified by time to MDA as in early (within 3 months), late (at 6–12 months), and never MDA in the first year. RESULTS: We included 296 patients who had had their 1-year outpatient visit (mean age 51 years, 53% male). Ninety-six (32%) were classified as early MDA, 78 (26%) as late MDA, and 98 (33%) as never MDA. Data of 24 patients (8%) were missing. SF36-PCS and productivity scores improved after gaining MDA, but remained low in never MDA patients. At 1 year, SF36-PCS and productivity scores were similar in early and late MDA patients. Radiographic progression rate was low and similar in all groups. CONCLUSION: Gaining MDA was associated with considerable improvement in HRQoL and functioning, irrespective of time to first MDA. In the one third of patients not in MDA in the first year, the disease had a substantial health impact. BioMed Central 2019-01-16 2019 /pmc/articles/PMC6335829/ /pubmed/30651121 http://dx.doi.org/10.1186/s13075-019-1811-4 Text en © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Wervers, Kim Luime, Jolanda J. Tchetverikov, Ilja Gerards, Andreas H. Kok, Marc R. Appels, Cathelijne W. Y. van der Graaff, Wiebo L. van Groenendael, Johannes H. L. M. Korswagen, Lindy-Anne Veris-van Dieren, Josien J. Hazes, Johanna M. W. Vis, Marijn Time to minimal disease activity in relation to quality of life, productivity, and radiographic damage 1 year after diagnosis in psoriatic arthritis |
title | Time to minimal disease activity in relation to quality of life, productivity, and radiographic damage 1 year after diagnosis in psoriatic arthritis |
title_full | Time to minimal disease activity in relation to quality of life, productivity, and radiographic damage 1 year after diagnosis in psoriatic arthritis |
title_fullStr | Time to minimal disease activity in relation to quality of life, productivity, and radiographic damage 1 year after diagnosis in psoriatic arthritis |
title_full_unstemmed | Time to minimal disease activity in relation to quality of life, productivity, and radiographic damage 1 year after diagnosis in psoriatic arthritis |
title_short | Time to minimal disease activity in relation to quality of life, productivity, and radiographic damage 1 year after diagnosis in psoriatic arthritis |
title_sort | time to minimal disease activity in relation to quality of life, productivity, and radiographic damage 1 year after diagnosis in psoriatic arthritis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335829/ https://www.ncbi.nlm.nih.gov/pubmed/30651121 http://dx.doi.org/10.1186/s13075-019-1811-4 |
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