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Triggering the expression of a silent gene cluster from genetically intractable bacteria results in scleric acid discovery
In this study, we report the rapid characterisation of a novel microbial natural product resulting from the rational derepression of a silent gene cluster. A conserved set of five regulatory genes was used as a query to search genomic databases and identify atypical biosynthetic gene clusters (BGCs)...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Royal Society of Chemistry
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335953/ https://www.ncbi.nlm.nih.gov/pubmed/30746093 http://dx.doi.org/10.1039/c8sc03814g |