The Zebrafish as an Emerging Model to Study DNA Damage in Aging, Cancer and Other Diseases

Cancer is a disease of the elderly, and old age is its largest risk factor. With age, DNA damage accumulates continuously, increasing the chance of malignant transformation. The zebrafish has emerged as an important vertebrate model to study these processes. Key mechanisms such as DNA damage respons...

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Autores principales: Cayuela, Maria Luisa, Claes, Kathleen B. M., Ferreira, Miguel Godinho, Henriques, Catarina Martins, van Eeden, Fredericus, Varga, Máté, Vierstraete, Jeroen, Mione, Maria Caterina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335974/
https://www.ncbi.nlm.nih.gov/pubmed/30687705
http://dx.doi.org/10.3389/fcell.2018.00178
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author Cayuela, Maria Luisa
Claes, Kathleen B. M.
Ferreira, Miguel Godinho
Henriques, Catarina Martins
van Eeden, Fredericus
Varga, Máté
Vierstraete, Jeroen
Mione, Maria Caterina
author_facet Cayuela, Maria Luisa
Claes, Kathleen B. M.
Ferreira, Miguel Godinho
Henriques, Catarina Martins
van Eeden, Fredericus
Varga, Máté
Vierstraete, Jeroen
Mione, Maria Caterina
author_sort Cayuela, Maria Luisa
collection PubMed
description Cancer is a disease of the elderly, and old age is its largest risk factor. With age, DNA damage accumulates continuously, increasing the chance of malignant transformation. The zebrafish has emerged as an important vertebrate model to study these processes. Key mechanisms such as DNA damage responses and cellular senescence can be studied in zebrafish throughout its life course. In addition, the zebrafish is becoming an important resource to study telomere biology in aging, regeneration and cancer. Here we review some of the tools and resources that zebrafish researchers have developed and discuss their potential use in the study of DNA damage, cancer and aging related diseases.
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spelling pubmed-63359742019-01-25 The Zebrafish as an Emerging Model to Study DNA Damage in Aging, Cancer and Other Diseases Cayuela, Maria Luisa Claes, Kathleen B. M. Ferreira, Miguel Godinho Henriques, Catarina Martins van Eeden, Fredericus Varga, Máté Vierstraete, Jeroen Mione, Maria Caterina Front Cell Dev Biol Physiology Cancer is a disease of the elderly, and old age is its largest risk factor. With age, DNA damage accumulates continuously, increasing the chance of malignant transformation. The zebrafish has emerged as an important vertebrate model to study these processes. Key mechanisms such as DNA damage responses and cellular senescence can be studied in zebrafish throughout its life course. In addition, the zebrafish is becoming an important resource to study telomere biology in aging, regeneration and cancer. Here we review some of the tools and resources that zebrafish researchers have developed and discuss their potential use in the study of DNA damage, cancer and aging related diseases. Frontiers Media S.A. 2019-01-10 /pmc/articles/PMC6335974/ /pubmed/30687705 http://dx.doi.org/10.3389/fcell.2018.00178 Text en Copyright © 2019 Cayuela, Claes, Ferreira, Henriques, van Eeden, Varga, Vierstraete and Mione. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Cayuela, Maria Luisa
Claes, Kathleen B. M.
Ferreira, Miguel Godinho
Henriques, Catarina Martins
van Eeden, Fredericus
Varga, Máté
Vierstraete, Jeroen
Mione, Maria Caterina
The Zebrafish as an Emerging Model to Study DNA Damage in Aging, Cancer and Other Diseases
title The Zebrafish as an Emerging Model to Study DNA Damage in Aging, Cancer and Other Diseases
title_full The Zebrafish as an Emerging Model to Study DNA Damage in Aging, Cancer and Other Diseases
title_fullStr The Zebrafish as an Emerging Model to Study DNA Damage in Aging, Cancer and Other Diseases
title_full_unstemmed The Zebrafish as an Emerging Model to Study DNA Damage in Aging, Cancer and Other Diseases
title_short The Zebrafish as an Emerging Model to Study DNA Damage in Aging, Cancer and Other Diseases
title_sort zebrafish as an emerging model to study dna damage in aging, cancer and other diseases
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335974/
https://www.ncbi.nlm.nih.gov/pubmed/30687705
http://dx.doi.org/10.3389/fcell.2018.00178
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