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Evaluation of relationship between bicuspid aortic valve phenotype with valve dysfunction and associated aortopathy

Introduction: Morphology of bicuspid aortic valve (BAV) may have implication in the associated pathologies including aortic stenosis (AS), aortic insufficiency (AI) and aortic dilation. The aim of this study is to investigate the frequency and patterns of valvular dysfunction and aortopathy associat...

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Autores principales: Toufan Tabrizi, Mehrnoush, Rahimi Asl, Roghaieh, Nazarnia, Soheyla, Pourafkari, Leili
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tabriz University of Medical Sciences 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335981/
https://www.ncbi.nlm.nih.gov/pubmed/30680084
http://dx.doi.org/10.15171/jcvtr.2018.41
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author Toufan Tabrizi, Mehrnoush
Rahimi Asl, Roghaieh
Nazarnia, Soheyla
Pourafkari, Leili
author_facet Toufan Tabrizi, Mehrnoush
Rahimi Asl, Roghaieh
Nazarnia, Soheyla
Pourafkari, Leili
author_sort Toufan Tabrizi, Mehrnoush
collection PubMed
description Introduction: Morphology of bicuspid aortic valve (BAV) may have implication in the associated pathologies including aortic stenosis (AS), aortic insufficiency (AI) and aortic dilation. The aim of this study is to investigate the frequency and patterns of valvular dysfunction and aortopathy associated with different phenotypes of BAV in a referral center in northwest of Iran. Methods: In this prospective study patients who presented to our echocardiography lab between January 2014 and December 2015 and were diagnosed with BAV were assessed. Frequency of various BAV phenotypes and their association with valvular dysfunction and aortopathy was evaluated. A P value less than 0.05 was considered statistically significant. Results: The average age of the study patients was 40±16 years, with predominance of male sex (72%). Patients with anteroposteriorly located BAV (BAV-AP) phenotype constituted majority of our cases with prevalence of 62.7%, while 37.3% of cases had right-left (BAV-RL) located valves. BAV-RL patients when compared to BAV-AP patients had higher frequencies of dilated aortic arch (25% vs. 4.3%, P < 0.001), AS (56.3% vs. 31.4%, P < 0.001), mass or vegetation on aortic valve (14.3 vs. 6.4%, P = 0.023) and lower frequencies of dilated aortic root (42.9% vs. 57.4%, P = 0.01), aortic insufficiency (68.8% vs. 79.8%, P = 0.034) and co-arctation of aorta (3.6% vs. 11.7%, P = 0.01). Conclusion: There seems to be a relationship between various BAV phenotypes, and frequency and pattern of aortic valve dysfunction and aortopathy. These findings suggest that examining leaflet morphology in BAV might help in risk stratification of these patients.
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spelling pubmed-63359812019-01-24 Evaluation of relationship between bicuspid aortic valve phenotype with valve dysfunction and associated aortopathy Toufan Tabrizi, Mehrnoush Rahimi Asl, Roghaieh Nazarnia, Soheyla Pourafkari, Leili J Cardiovasc Thorac Res Original Article Introduction: Morphology of bicuspid aortic valve (BAV) may have implication in the associated pathologies including aortic stenosis (AS), aortic insufficiency (AI) and aortic dilation. The aim of this study is to investigate the frequency and patterns of valvular dysfunction and aortopathy associated with different phenotypes of BAV in a referral center in northwest of Iran. Methods: In this prospective study patients who presented to our echocardiography lab between January 2014 and December 2015 and were diagnosed with BAV were assessed. Frequency of various BAV phenotypes and their association with valvular dysfunction and aortopathy was evaluated. A P value less than 0.05 was considered statistically significant. Results: The average age of the study patients was 40±16 years, with predominance of male sex (72%). Patients with anteroposteriorly located BAV (BAV-AP) phenotype constituted majority of our cases with prevalence of 62.7%, while 37.3% of cases had right-left (BAV-RL) located valves. BAV-RL patients when compared to BAV-AP patients had higher frequencies of dilated aortic arch (25% vs. 4.3%, P < 0.001), AS (56.3% vs. 31.4%, P < 0.001), mass or vegetation on aortic valve (14.3 vs. 6.4%, P = 0.023) and lower frequencies of dilated aortic root (42.9% vs. 57.4%, P = 0.01), aortic insufficiency (68.8% vs. 79.8%, P = 0.034) and co-arctation of aorta (3.6% vs. 11.7%, P = 0.01). Conclusion: There seems to be a relationship between various BAV phenotypes, and frequency and pattern of aortic valve dysfunction and aortopathy. These findings suggest that examining leaflet morphology in BAV might help in risk stratification of these patients. Tabriz University of Medical Sciences 2018 2018-12-13 /pmc/articles/PMC6335981/ /pubmed/30680084 http://dx.doi.org/10.15171/jcvtr.2018.41 Text en © 2018 The Author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Toufan Tabrizi, Mehrnoush
Rahimi Asl, Roghaieh
Nazarnia, Soheyla
Pourafkari, Leili
Evaluation of relationship between bicuspid aortic valve phenotype with valve dysfunction and associated aortopathy
title Evaluation of relationship between bicuspid aortic valve phenotype with valve dysfunction and associated aortopathy
title_full Evaluation of relationship between bicuspid aortic valve phenotype with valve dysfunction and associated aortopathy
title_fullStr Evaluation of relationship between bicuspid aortic valve phenotype with valve dysfunction and associated aortopathy
title_full_unstemmed Evaluation of relationship between bicuspid aortic valve phenotype with valve dysfunction and associated aortopathy
title_short Evaluation of relationship between bicuspid aortic valve phenotype with valve dysfunction and associated aortopathy
title_sort evaluation of relationship between bicuspid aortic valve phenotype with valve dysfunction and associated aortopathy
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335981/
https://www.ncbi.nlm.nih.gov/pubmed/30680084
http://dx.doi.org/10.15171/jcvtr.2018.41
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