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Patients With Lean Nonalcoholic Fatty Liver Disease Are Metabolically Abnormal and Have a Higher Risk for Mortality

IN BRIEF Nonalcoholic fatty liver disease (NAFLD) is an increasingly recognized and common cause of chronic liver disease worldwide. Although most patients with NAFLD are obese, a smaller group of NAFLD patients are lean. This study explored the long-term outcomes of lean patients with NAFLD in the...

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Autores principales: Golabi, Pegah, Paik, James, Fukui, Natsu, Locklear, Cameron T., de Avilla, Leyla, Younossi, Zobair M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336127/
https://www.ncbi.nlm.nih.gov/pubmed/30705499
http://dx.doi.org/10.2337/cd18-0026
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author Golabi, Pegah
Paik, James
Fukui, Natsu
Locklear, Cameron T.
de Avilla, Leyla
Younossi, Zobair M.
author_facet Golabi, Pegah
Paik, James
Fukui, Natsu
Locklear, Cameron T.
de Avilla, Leyla
Younossi, Zobair M.
author_sort Golabi, Pegah
collection PubMed
description IN BRIEF Nonalcoholic fatty liver disease (NAFLD) is an increasingly recognized and common cause of chronic liver disease worldwide. Although most patients with NAFLD are obese, a smaller group of NAFLD patients are lean. This study explored the long-term outcomes of lean patients with NAFLD in the United States. Compared to lean individuals without NAFLD, lean people with NAFLD were significantly more likely to be older and male and had higher comorbidities (i.e., diabetes, hyperlipidemia, hypertension, metabolic syndrome, chronic kidney disease, and cardiovascular disease). The presence of NAFLD in lean individuals was independently associated with increased risk of all-cause and cardiovascular mortality.
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spelling pubmed-63361272020-01-01 Patients With Lean Nonalcoholic Fatty Liver Disease Are Metabolically Abnormal and Have a Higher Risk for Mortality Golabi, Pegah Paik, James Fukui, Natsu Locklear, Cameron T. de Avilla, Leyla Younossi, Zobair M. Clin Diabetes Feature Articles IN BRIEF Nonalcoholic fatty liver disease (NAFLD) is an increasingly recognized and common cause of chronic liver disease worldwide. Although most patients with NAFLD are obese, a smaller group of NAFLD patients are lean. This study explored the long-term outcomes of lean patients with NAFLD in the United States. Compared to lean individuals without NAFLD, lean people with NAFLD were significantly more likely to be older and male and had higher comorbidities (i.e., diabetes, hyperlipidemia, hypertension, metabolic syndrome, chronic kidney disease, and cardiovascular disease). The presence of NAFLD in lean individuals was independently associated with increased risk of all-cause and cardiovascular mortality. American Diabetes Association 2019-01 /pmc/articles/PMC6336127/ /pubmed/30705499 http://dx.doi.org/10.2337/cd18-0026 Text en © 2019 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0 for details.
spellingShingle Feature Articles
Golabi, Pegah
Paik, James
Fukui, Natsu
Locklear, Cameron T.
de Avilla, Leyla
Younossi, Zobair M.
Patients With Lean Nonalcoholic Fatty Liver Disease Are Metabolically Abnormal and Have a Higher Risk for Mortality
title Patients With Lean Nonalcoholic Fatty Liver Disease Are Metabolically Abnormal and Have a Higher Risk for Mortality
title_full Patients With Lean Nonalcoholic Fatty Liver Disease Are Metabolically Abnormal and Have a Higher Risk for Mortality
title_fullStr Patients With Lean Nonalcoholic Fatty Liver Disease Are Metabolically Abnormal and Have a Higher Risk for Mortality
title_full_unstemmed Patients With Lean Nonalcoholic Fatty Liver Disease Are Metabolically Abnormal and Have a Higher Risk for Mortality
title_short Patients With Lean Nonalcoholic Fatty Liver Disease Are Metabolically Abnormal and Have a Higher Risk for Mortality
title_sort patients with lean nonalcoholic fatty liver disease are metabolically abnormal and have a higher risk for mortality
topic Feature Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336127/
https://www.ncbi.nlm.nih.gov/pubmed/30705499
http://dx.doi.org/10.2337/cd18-0026
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