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Patients With Lean Nonalcoholic Fatty Liver Disease Are Metabolically Abnormal and Have a Higher Risk for Mortality
IN BRIEF Nonalcoholic fatty liver disease (NAFLD) is an increasingly recognized and common cause of chronic liver disease worldwide. Although most patients with NAFLD are obese, a smaller group of NAFLD patients are lean. This study explored the long-term outcomes of lean patients with NAFLD in the...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Diabetes Association
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336127/ https://www.ncbi.nlm.nih.gov/pubmed/30705499 http://dx.doi.org/10.2337/cd18-0026 |
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author | Golabi, Pegah Paik, James Fukui, Natsu Locklear, Cameron T. de Avilla, Leyla Younossi, Zobair M. |
author_facet | Golabi, Pegah Paik, James Fukui, Natsu Locklear, Cameron T. de Avilla, Leyla Younossi, Zobair M. |
author_sort | Golabi, Pegah |
collection | PubMed |
description | IN BRIEF Nonalcoholic fatty liver disease (NAFLD) is an increasingly recognized and common cause of chronic liver disease worldwide. Although most patients with NAFLD are obese, a smaller group of NAFLD patients are lean. This study explored the long-term outcomes of lean patients with NAFLD in the United States. Compared to lean individuals without NAFLD, lean people with NAFLD were significantly more likely to be older and male and had higher comorbidities (i.e., diabetes, hyperlipidemia, hypertension, metabolic syndrome, chronic kidney disease, and cardiovascular disease). The presence of NAFLD in lean individuals was independently associated with increased risk of all-cause and cardiovascular mortality. |
format | Online Article Text |
id | pubmed-6336127 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | American Diabetes Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-63361272020-01-01 Patients With Lean Nonalcoholic Fatty Liver Disease Are Metabolically Abnormal and Have a Higher Risk for Mortality Golabi, Pegah Paik, James Fukui, Natsu Locklear, Cameron T. de Avilla, Leyla Younossi, Zobair M. Clin Diabetes Feature Articles IN BRIEF Nonalcoholic fatty liver disease (NAFLD) is an increasingly recognized and common cause of chronic liver disease worldwide. Although most patients with NAFLD are obese, a smaller group of NAFLD patients are lean. This study explored the long-term outcomes of lean patients with NAFLD in the United States. Compared to lean individuals without NAFLD, lean people with NAFLD were significantly more likely to be older and male and had higher comorbidities (i.e., diabetes, hyperlipidemia, hypertension, metabolic syndrome, chronic kidney disease, and cardiovascular disease). The presence of NAFLD in lean individuals was independently associated with increased risk of all-cause and cardiovascular mortality. American Diabetes Association 2019-01 /pmc/articles/PMC6336127/ /pubmed/30705499 http://dx.doi.org/10.2337/cd18-0026 Text en © 2019 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0 for details. |
spellingShingle | Feature Articles Golabi, Pegah Paik, James Fukui, Natsu Locklear, Cameron T. de Avilla, Leyla Younossi, Zobair M. Patients With Lean Nonalcoholic Fatty Liver Disease Are Metabolically Abnormal and Have a Higher Risk for Mortality |
title | Patients With Lean Nonalcoholic Fatty Liver Disease Are Metabolically Abnormal and Have a Higher Risk for Mortality |
title_full | Patients With Lean Nonalcoholic Fatty Liver Disease Are Metabolically Abnormal and Have a Higher Risk for Mortality |
title_fullStr | Patients With Lean Nonalcoholic Fatty Liver Disease Are Metabolically Abnormal and Have a Higher Risk for Mortality |
title_full_unstemmed | Patients With Lean Nonalcoholic Fatty Liver Disease Are Metabolically Abnormal and Have a Higher Risk for Mortality |
title_short | Patients With Lean Nonalcoholic Fatty Liver Disease Are Metabolically Abnormal and Have a Higher Risk for Mortality |
title_sort | patients with lean nonalcoholic fatty liver disease are metabolically abnormal and have a higher risk for mortality |
topic | Feature Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336127/ https://www.ncbi.nlm.nih.gov/pubmed/30705499 http://dx.doi.org/10.2337/cd18-0026 |
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