Cargando…
A symbiotic supramolecular approach to the design of novel amphiphiles with antibacterial properties against MSRA
Herein, we identify supramolecular self-associating amphiphiles (SSAs) as a novel class of antibacterials with activity towards methicillin-resistant Staphylococcus aureus. Structure–activity relationships have been identified in the solid, solution and gas phases. Finally, we show that when supplie...
| Autores principales: | , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Royal Society of Chemistry
2019
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336146/ https://www.ncbi.nlm.nih.gov/pubmed/30512024 http://dx.doi.org/10.1039/c8cc08485h |
| _version_ | 1783388012446482432 |
|---|---|
| author | Tyuleva, Stilyana N. Allen, Nyasha White, Lisa J. Pépés, Antigoni Shepherd, Helena J. Saines, Paul J. Ellaby, Rebecca J. Mulvihill, Daniel P. Hiscock, Jennifer R. |
| author_facet | Tyuleva, Stilyana N. Allen, Nyasha White, Lisa J. Pépés, Antigoni Shepherd, Helena J. Saines, Paul J. Ellaby, Rebecca J. Mulvihill, Daniel P. Hiscock, Jennifer R. |
| author_sort | Tyuleva, Stilyana N. |
| collection | PubMed |
| description | Herein, we identify supramolecular self-associating amphiphiles (SSAs) as a novel class of antibacterials with activity towards methicillin-resistant Staphylococcus aureus. Structure–activity relationships have been identified in the solid, solution and gas phases. Finally, we show that when supplied in combination, SSAs exhibit increased antibacterial efficacy against these clinically relevant microbes. |
| format | Online Article Text |
| id | pubmed-6336146 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| publisher | Royal Society of Chemistry |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-63361462019-02-11 A symbiotic supramolecular approach to the design of novel amphiphiles with antibacterial properties against MSRA Tyuleva, Stilyana N. Allen, Nyasha White, Lisa J. Pépés, Antigoni Shepherd, Helena J. Saines, Paul J. Ellaby, Rebecca J. Mulvihill, Daniel P. Hiscock, Jennifer R. Chem Commun (Camb) Chemistry Herein, we identify supramolecular self-associating amphiphiles (SSAs) as a novel class of antibacterials with activity towards methicillin-resistant Staphylococcus aureus. Structure–activity relationships have been identified in the solid, solution and gas phases. Finally, we show that when supplied in combination, SSAs exhibit increased antibacterial efficacy against these clinically relevant microbes. Royal Society of Chemistry 2019-01-04 2018-12-04 /pmc/articles/PMC6336146/ /pubmed/30512024 http://dx.doi.org/10.1039/c8cc08485h Text en This journal is © The Royal Society of Chemistry 2019 http://creativecommons.org/licenses/by/3.0/ This article is freely available. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (CC BY 3.0) |
| spellingShingle | Chemistry Tyuleva, Stilyana N. Allen, Nyasha White, Lisa J. Pépés, Antigoni Shepherd, Helena J. Saines, Paul J. Ellaby, Rebecca J. Mulvihill, Daniel P. Hiscock, Jennifer R. A symbiotic supramolecular approach to the design of novel amphiphiles with antibacterial properties against MSRA |
| title | A symbiotic supramolecular approach to the design of novel amphiphiles with antibacterial properties against MSRA
|
| title_full | A symbiotic supramolecular approach to the design of novel amphiphiles with antibacterial properties against MSRA
|
| title_fullStr | A symbiotic supramolecular approach to the design of novel amphiphiles with antibacterial properties against MSRA
|
| title_full_unstemmed | A symbiotic supramolecular approach to the design of novel amphiphiles with antibacterial properties against MSRA
|
| title_short | A symbiotic supramolecular approach to the design of novel amphiphiles with antibacterial properties against MSRA
|
| title_sort | symbiotic supramolecular approach to the design of novel amphiphiles with antibacterial properties against msra |
| topic | Chemistry |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336146/ https://www.ncbi.nlm.nih.gov/pubmed/30512024 http://dx.doi.org/10.1039/c8cc08485h |
| work_keys_str_mv | AT tyulevastilyanan asymbioticsupramolecularapproachtothedesignofnovelamphiphileswithantibacterialpropertiesagainstmsra AT allennyasha asymbioticsupramolecularapproachtothedesignofnovelamphiphileswithantibacterialpropertiesagainstmsra AT whitelisaj asymbioticsupramolecularapproachtothedesignofnovelamphiphileswithantibacterialpropertiesagainstmsra AT pepesantigoni asymbioticsupramolecularapproachtothedesignofnovelamphiphileswithantibacterialpropertiesagainstmsra AT shepherdhelenaj asymbioticsupramolecularapproachtothedesignofnovelamphiphileswithantibacterialpropertiesagainstmsra AT sainespaulj asymbioticsupramolecularapproachtothedesignofnovelamphiphileswithantibacterialpropertiesagainstmsra AT ellabyrebeccaj asymbioticsupramolecularapproachtothedesignofnovelamphiphileswithantibacterialpropertiesagainstmsra AT mulvihilldanielp asymbioticsupramolecularapproachtothedesignofnovelamphiphileswithantibacterialpropertiesagainstmsra AT hiscockjenniferr asymbioticsupramolecularapproachtothedesignofnovelamphiphileswithantibacterialpropertiesagainstmsra AT tyulevastilyanan symbioticsupramolecularapproachtothedesignofnovelamphiphileswithantibacterialpropertiesagainstmsra AT allennyasha symbioticsupramolecularapproachtothedesignofnovelamphiphileswithantibacterialpropertiesagainstmsra AT whitelisaj symbioticsupramolecularapproachtothedesignofnovelamphiphileswithantibacterialpropertiesagainstmsra AT pepesantigoni symbioticsupramolecularapproachtothedesignofnovelamphiphileswithantibacterialpropertiesagainstmsra AT shepherdhelenaj symbioticsupramolecularapproachtothedesignofnovelamphiphileswithantibacterialpropertiesagainstmsra AT sainespaulj symbioticsupramolecularapproachtothedesignofnovelamphiphileswithantibacterialpropertiesagainstmsra AT ellabyrebeccaj symbioticsupramolecularapproachtothedesignofnovelamphiphileswithantibacterialpropertiesagainstmsra AT mulvihilldanielp symbioticsupramolecularapproachtothedesignofnovelamphiphileswithantibacterialpropertiesagainstmsra AT hiscockjenniferr symbioticsupramolecularapproachtothedesignofnovelamphiphileswithantibacterialpropertiesagainstmsra |