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Activation of AMPK/SIRT1 axis is required for adiponectin-mediated preconditioning on myocardial ischemia-reperfusion (I/R) injury in rats

BACKGROUND: Adiponectin (AD) cardioprotective activities are mediated by AMPK, a fuel-sensing molecule sharing common targets and cellular activities with SIRT-1. Whether AD preconditioning may involve SIRT-1 activity is not known; however, the protective role of SIRT-1 during ischemia and the poten...

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Detalles Bibliográficos
Autores principales:	Potenza, Maria Assunta, Sgarra, Luca, Nacci, Carmela, Leo, Valentina, De Salvia, Maria Antonietta, Montagnani, Monica
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336234/ https://www.ncbi.nlm.nih.gov/pubmed/30653603 http://dx.doi.org/10.1371/journal.pone.0210654

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