EBNA3C facilitates RASSF1A downregulation through ubiquitin-mediated degradation and promoter hypermethylation to drive B-cell proliferation

EBV latent antigen 3C (EBNA3C) is essential for EBV-induced primary B-cell transformation. Infection by EBV induces hypermethylation of a number of tumor suppressor genes, which contributes to the development of human cancers. The Ras association domain family isoform 1A (RASSF1A) is a cellular tumo...

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Detalles Bibliográficos
Autores principales: Zhang, Shengwei, Pei, Yonggang, Lang, Fengchao, Sun, Kunfeng, Singh, Rajnish Kumar, Lamplugh, Zachary L., Saha, Abhik, Robertson, Erle S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336319/
https://www.ncbi.nlm.nih.gov/pubmed/30615685
http://dx.doi.org/10.1371/journal.ppat.1007514

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