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Sildenafil does not improve performance in 16.1 km cycle exercise time-trial in acute hypoxia
Sildenafil is a pulmonary vasodilator that has potential to mitigate the decrement in endurance performance caused by hypoxic pulmonary vasoconstriction. The purpose of this study was to determine the effects of sildenafil on pulmonary artery pressure, cardiac output, pulse oxygen saturation, and ex...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336365/ https://www.ncbi.nlm.nih.gov/pubmed/30653578 http://dx.doi.org/10.1371/journal.pone.0210841 |
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author | Carter, Eric A. Sheel, A. William Milsom, William K. Koehle, Michael S. |
author_facet | Carter, Eric A. Sheel, A. William Milsom, William K. Koehle, Michael S. |
author_sort | Carter, Eric A. |
collection | PubMed |
description | Sildenafil is a pulmonary vasodilator that has potential to mitigate the decrement in endurance performance caused by hypoxic pulmonary vasoconstriction. The purpose of this study was to determine the effects of sildenafil on pulmonary artery pressure, cardiac output, pulse oxygen saturation, and exercise performance at moderate simulated altitude. We hypothesized that sildenafil would reduce the decline in exercise performance in hypoxia by blunting the rise in pulmonary artery pressure and causing a relative increase in cardiac output and oxygen saturation. Twelve endurance trained men performed three experimental cycling trials at sea level and simulated moderate altitude of 3,000m (F(I)O(2) = 0.147) after ingesting either a placebo or sildenafil 50 mg capsule in a double blinded fashion. Each test consisted of a warmup period, a 15-minute steady state period at 60% of peak power output, and a 16.1 km time-trial. All subjects experienced a decline in maximal exercise capacity in hypoxia that ranged from 6% to 24%. This decline was correlated with the reduction in pulse oxygen saturation in hypoxic maximal exercise. Sildenafil had no effect on pulmonary artery pressure, cardiac output, or pulse oxygen saturation measured during steady state exercise. There was no effect of sildenafil on mean power output during the time-trial. During high intensity cycle exercise in acute, moderate hypoxia pulmonary artery pressure is unaffected by sildenafil and does not appear to influence cardiovascular function or exercise performance. |
format | Online Article Text |
id | pubmed-6336365 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-63363652019-01-30 Sildenafil does not improve performance in 16.1 km cycle exercise time-trial in acute hypoxia Carter, Eric A. Sheel, A. William Milsom, William K. Koehle, Michael S. PLoS One Research Article Sildenafil is a pulmonary vasodilator that has potential to mitigate the decrement in endurance performance caused by hypoxic pulmonary vasoconstriction. The purpose of this study was to determine the effects of sildenafil on pulmonary artery pressure, cardiac output, pulse oxygen saturation, and exercise performance at moderate simulated altitude. We hypothesized that sildenafil would reduce the decline in exercise performance in hypoxia by blunting the rise in pulmonary artery pressure and causing a relative increase in cardiac output and oxygen saturation. Twelve endurance trained men performed three experimental cycling trials at sea level and simulated moderate altitude of 3,000m (F(I)O(2) = 0.147) after ingesting either a placebo or sildenafil 50 mg capsule in a double blinded fashion. Each test consisted of a warmup period, a 15-minute steady state period at 60% of peak power output, and a 16.1 km time-trial. All subjects experienced a decline in maximal exercise capacity in hypoxia that ranged from 6% to 24%. This decline was correlated with the reduction in pulse oxygen saturation in hypoxic maximal exercise. Sildenafil had no effect on pulmonary artery pressure, cardiac output, or pulse oxygen saturation measured during steady state exercise. There was no effect of sildenafil on mean power output during the time-trial. During high intensity cycle exercise in acute, moderate hypoxia pulmonary artery pressure is unaffected by sildenafil and does not appear to influence cardiovascular function or exercise performance. Public Library of Science 2019-01-17 /pmc/articles/PMC6336365/ /pubmed/30653578 http://dx.doi.org/10.1371/journal.pone.0210841 Text en © 2019 Carter et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Carter, Eric A. Sheel, A. William Milsom, William K. Koehle, Michael S. Sildenafil does not improve performance in 16.1 km cycle exercise time-trial in acute hypoxia |
title | Sildenafil does not improve performance in 16.1 km cycle exercise time-trial in acute hypoxia |
title_full | Sildenafil does not improve performance in 16.1 km cycle exercise time-trial in acute hypoxia |
title_fullStr | Sildenafil does not improve performance in 16.1 km cycle exercise time-trial in acute hypoxia |
title_full_unstemmed | Sildenafil does not improve performance in 16.1 km cycle exercise time-trial in acute hypoxia |
title_short | Sildenafil does not improve performance in 16.1 km cycle exercise time-trial in acute hypoxia |
title_sort | sildenafil does not improve performance in 16.1 km cycle exercise time-trial in acute hypoxia |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336365/ https://www.ncbi.nlm.nih.gov/pubmed/30653578 http://dx.doi.org/10.1371/journal.pone.0210841 |
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