GREB1 amplifies androgen receptor output in human prostate cancer and contributes to antiandrogen resistance

Genomic amplification of the androgen receptor (AR) is an established mechanism of antiandrogen resistance in prostate cancer. Here, we show that the magnitude of AR signaling output, independent of AR genomic alteration or expression level, also contributes to antiandrogen resistance, through upreg...

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Detalles Bibliográficos
Autores principales: Lee, Eugine, Wongvipat, John, Choi, Danielle, Wang, Ping, Lee, Young Sun, Zheng, Deyou, Watson, Philip A, Gopalan, Anuradha, Sawyers, Charles L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336405/
https://www.ncbi.nlm.nih.gov/pubmed/30644358
http://dx.doi.org/10.7554/eLife.41913

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336405/
https://www.ncbi.nlm.nih.gov/pubmed/30644358
http://dx.doi.org/10.7554/eLife.41913

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