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Decreased brain connectivity in smoking contrasts with increased connectivity in drinking

In a group of 831 participants from the general population in the Human Connectome Project, smokers exhibited low overall functional connectivity, and more specifically of the lateral orbitofrontal cortex which is associated with non-reward mechanisms, the adjacent inferior frontal gyrus, and the pr...

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Autores principales: Cheng, Wei, Rolls, Edmund T, Robbins, Trevor W, Gong, Weikang, Liu, Zhaowen, Lv, Wujun, Du, Jingnan, Wen, Hongkai, Ma, Liang, Quinlan, Erin Burke, Garavan, Hugh, Artiges, Eric, Papadopoulos Orfanos, Dimitri, Smolka, Michael N, Schumann, Gunter, Kendrick, Keith, Feng, Jianfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336408/
https://www.ncbi.nlm.nih.gov/pubmed/30616717
http://dx.doi.org/10.7554/eLife.40765
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author Cheng, Wei
Rolls, Edmund T
Robbins, Trevor W
Gong, Weikang
Liu, Zhaowen
Lv, Wujun
Du, Jingnan
Wen, Hongkai
Ma, Liang
Quinlan, Erin Burke
Garavan, Hugh
Artiges, Eric
Papadopoulos Orfanos, Dimitri
Smolka, Michael N
Schumann, Gunter
Kendrick, Keith
Feng, Jianfeng
author_facet Cheng, Wei
Rolls, Edmund T
Robbins, Trevor W
Gong, Weikang
Liu, Zhaowen
Lv, Wujun
Du, Jingnan
Wen, Hongkai
Ma, Liang
Quinlan, Erin Burke
Garavan, Hugh
Artiges, Eric
Papadopoulos Orfanos, Dimitri
Smolka, Michael N
Schumann, Gunter
Kendrick, Keith
Feng, Jianfeng
author_sort Cheng, Wei
collection PubMed
description In a group of 831 participants from the general population in the Human Connectome Project, smokers exhibited low overall functional connectivity, and more specifically of the lateral orbitofrontal cortex which is associated with non-reward mechanisms, the adjacent inferior frontal gyrus, and the precuneus. Participants who drank a high amount had overall increases in resting state functional connectivity, and specific increases in reward-related systems including the medial orbitofrontal cortex and the cingulate cortex. Increased impulsivity was found in smokers, associated with decreased functional connectivity of the non-reward-related lateral orbitofrontal cortex; and increased impulsivity was found in high amount drinkers, associated with increased functional connectivity of the reward-related medial orbitofrontal cortex. The main findings were cross-validated in an independent longitudinal dataset with 1176 participants, IMAGEN. Further, the functional connectivities in 14-year-old non-smokers (and also in female low-drinkers) were related to who would smoke or drink at age 19. An implication is that these differences in brain functional connectivities play a role in smoking and drinking, together with other factors.
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spelling pubmed-63364082019-01-24 Decreased brain connectivity in smoking contrasts with increased connectivity in drinking Cheng, Wei Rolls, Edmund T Robbins, Trevor W Gong, Weikang Liu, Zhaowen Lv, Wujun Du, Jingnan Wen, Hongkai Ma, Liang Quinlan, Erin Burke Garavan, Hugh Artiges, Eric Papadopoulos Orfanos, Dimitri Smolka, Michael N Schumann, Gunter Kendrick, Keith Feng, Jianfeng eLife Neuroscience In a group of 831 participants from the general population in the Human Connectome Project, smokers exhibited low overall functional connectivity, and more specifically of the lateral orbitofrontal cortex which is associated with non-reward mechanisms, the adjacent inferior frontal gyrus, and the precuneus. Participants who drank a high amount had overall increases in resting state functional connectivity, and specific increases in reward-related systems including the medial orbitofrontal cortex and the cingulate cortex. Increased impulsivity was found in smokers, associated with decreased functional connectivity of the non-reward-related lateral orbitofrontal cortex; and increased impulsivity was found in high amount drinkers, associated with increased functional connectivity of the reward-related medial orbitofrontal cortex. The main findings were cross-validated in an independent longitudinal dataset with 1176 participants, IMAGEN. Further, the functional connectivities in 14-year-old non-smokers (and also in female low-drinkers) were related to who would smoke or drink at age 19. An implication is that these differences in brain functional connectivities play a role in smoking and drinking, together with other factors. eLife Sciences Publications, Ltd 2019-01-08 /pmc/articles/PMC6336408/ /pubmed/30616717 http://dx.doi.org/10.7554/eLife.40765 Text en © 2019, Cheng et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Cheng, Wei
Rolls, Edmund T
Robbins, Trevor W
Gong, Weikang
Liu, Zhaowen
Lv, Wujun
Du, Jingnan
Wen, Hongkai
Ma, Liang
Quinlan, Erin Burke
Garavan, Hugh
Artiges, Eric
Papadopoulos Orfanos, Dimitri
Smolka, Michael N
Schumann, Gunter
Kendrick, Keith
Feng, Jianfeng
Decreased brain connectivity in smoking contrasts with increased connectivity in drinking
title Decreased brain connectivity in smoking contrasts with increased connectivity in drinking
title_full Decreased brain connectivity in smoking contrasts with increased connectivity in drinking
title_fullStr Decreased brain connectivity in smoking contrasts with increased connectivity in drinking
title_full_unstemmed Decreased brain connectivity in smoking contrasts with increased connectivity in drinking
title_short Decreased brain connectivity in smoking contrasts with increased connectivity in drinking
title_sort decreased brain connectivity in smoking contrasts with increased connectivity in drinking
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336408/
https://www.ncbi.nlm.nih.gov/pubmed/30616717
http://dx.doi.org/10.7554/eLife.40765
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