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Crystal structure of a natural light-gated anion channelrhodopsin

The anion channelrhodopsin GtACR1 from the alga Guillardia theta is a potent neuron-inhibiting optogenetics tool. Presented here, its X-ray structure at 2.9 Å reveals a tunnel traversing the protein from its extracellular surface to a large cytoplasmic cavity. The tunnel is lined primarily by small...

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Detalles Bibliográficos
Autores principales:	Li, Hai, Huang, Chia-Ying, Govorunova, Elena G, Schafer, Christopher T, Sineshchekov, Oleg A, Wang, Meitian, Zheng, Lei, Spudich, John L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2019
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336409/ https://www.ncbi.nlm.nih.gov/pubmed/30614787 http://dx.doi.org/10.7554/eLife.41741

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