Nanocrystals: A perspective on translational research and clinical studies

Poorly soluble small molecules typically pose translational hurdles owing to their low solubility, low bioavailability, and formulation challenges. Nanocrystallization is a versatile method for salvaging poorly soluble drugs with the added benefit of a carrier‐free delivery system. In this review, w...

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Detalles Bibliográficos
Autores principales: Jarvis, Maria, Krishnan, Vinu, Mitragotri, Samir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336669/
https://www.ncbi.nlm.nih.gov/pubmed/30680314
http://dx.doi.org/10.1002/btm2.10122
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author Jarvis, Maria
Krishnan, Vinu
Mitragotri, Samir
author_facet Jarvis, Maria
Krishnan, Vinu
Mitragotri, Samir
author_sort Jarvis, Maria
collection PubMed
description Poorly soluble small molecules typically pose translational hurdles owing to their low solubility, low bioavailability, and formulation challenges. Nanocrystallization is a versatile method for salvaging poorly soluble drugs with the added benefit of a carrier‐free delivery system. In this review, we provide a comprehensive analysis of nanocrystals with emphasis on their clinical translation. Additionally, the review sheds light on clinically approved nanocrystal drug products as well as those in development.
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spelling pubmed-63366692019-01-24 Nanocrystals: A perspective on translational research and clinical studies Jarvis, Maria Krishnan, Vinu Mitragotri, Samir Bioeng Transl Med Review Poorly soluble small molecules typically pose translational hurdles owing to their low solubility, low bioavailability, and formulation challenges. Nanocrystallization is a versatile method for salvaging poorly soluble drugs with the added benefit of a carrier‐free delivery system. In this review, we provide a comprehensive analysis of nanocrystals with emphasis on their clinical translation. Additionally, the review sheds light on clinically approved nanocrystal drug products as well as those in development. John Wiley & Sons, Inc. 2018-12-24 /pmc/articles/PMC6336669/ /pubmed/30680314 http://dx.doi.org/10.1002/btm2.10122 Text en © 2018 The Authors. Bioengineering & Translational Medicine published by Wiley Periodicals, Inc. on behalf of The American Institute of Chemical Engineers. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Jarvis, Maria
Krishnan, Vinu
Mitragotri, Samir
Nanocrystals: A perspective on translational research and clinical studies
title Nanocrystals: A perspective on translational research and clinical studies
title_full Nanocrystals: A perspective on translational research and clinical studies
title_fullStr Nanocrystals: A perspective on translational research and clinical studies
title_full_unstemmed Nanocrystals: A perspective on translational research and clinical studies
title_short Nanocrystals: A perspective on translational research and clinical studies
title_sort nanocrystals: a perspective on translational research and clinical studies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336669/
https://www.ncbi.nlm.nih.gov/pubmed/30680314
http://dx.doi.org/10.1002/btm2.10122
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AT mitragotrisamir nanocrystalsaperspectiveontranslationalresearchandclinicalstudies

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