Cargando…

Applications of decellularized extracellular matrix in bone and cartilage tissue engineering

Regenerative therapies for bone and cartilage injuries are currently unable to replicate the complex microenvironment of native tissue. There are many tissue engineering approaches attempting to address this issue through the use of synthetic materials. Although synthetic materials can be modified t...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Yu Seon, Majid, Marjan, Melchiorri, Anthony J., Mikos, Antonios G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336671/
https://www.ncbi.nlm.nih.gov/pubmed/30680321
http://dx.doi.org/10.1002/btm2.10110
_version_ 1783388091921203200
author Kim, Yu Seon
Majid, Marjan
Melchiorri, Anthony J.
Mikos, Antonios G.
author_facet Kim, Yu Seon
Majid, Marjan
Melchiorri, Anthony J.
Mikos, Antonios G.
author_sort Kim, Yu Seon
collection PubMed
description Regenerative therapies for bone and cartilage injuries are currently unable to replicate the complex microenvironment of native tissue. There are many tissue engineering approaches attempting to address this issue through the use of synthetic materials. Although synthetic materials can be modified to simulate the mechanical and biochemical properties of the cell microenvironment, they do not mimic in full the multitude of interactions that take place within tissue. Decellularized extracellular matrix (dECM) has been established as a biomaterial that preserves a tissue's native environment, promotes cell proliferation, and provides cues for cell differentiation. The potential of dECM as a therapeutic agent is rising, but there are many limitations of dECM restricting its use. This review discusses the recent progress in the utilization of bone and cartilage dECM through applications as scaffolds, particles, and supplementary factors in bone and cartilage tissue engineering.
format Online
Article
Text
id pubmed-6336671
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-63366712019-01-24 Applications of decellularized extracellular matrix in bone and cartilage tissue engineering Kim, Yu Seon Majid, Marjan Melchiorri, Anthony J. Mikos, Antonios G. Bioeng Transl Med Reviews Regenerative therapies for bone and cartilage injuries are currently unable to replicate the complex microenvironment of native tissue. There are many tissue engineering approaches attempting to address this issue through the use of synthetic materials. Although synthetic materials can be modified to simulate the mechanical and biochemical properties of the cell microenvironment, they do not mimic in full the multitude of interactions that take place within tissue. Decellularized extracellular matrix (dECM) has been established as a biomaterial that preserves a tissue's native environment, promotes cell proliferation, and provides cues for cell differentiation. The potential of dECM as a therapeutic agent is rising, but there are many limitations of dECM restricting its use. This review discusses the recent progress in the utilization of bone and cartilage dECM through applications as scaffolds, particles, and supplementary factors in bone and cartilage tissue engineering. John Wiley and Sons Inc. 2018-10-26 /pmc/articles/PMC6336671/ /pubmed/30680321 http://dx.doi.org/10.1002/btm2.10110 Text en © 2018 The Authors. Bioengineering & Translational Medicine published by Wiley Periodicals, Inc. on behalf of The American Institute of Chemical Engineers. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Kim, Yu Seon
Majid, Marjan
Melchiorri, Anthony J.
Mikos, Antonios G.
Applications of decellularized extracellular matrix in bone and cartilage tissue engineering
title Applications of decellularized extracellular matrix in bone and cartilage tissue engineering
title_full Applications of decellularized extracellular matrix in bone and cartilage tissue engineering
title_fullStr Applications of decellularized extracellular matrix in bone and cartilage tissue engineering
title_full_unstemmed Applications of decellularized extracellular matrix in bone and cartilage tissue engineering
title_short Applications of decellularized extracellular matrix in bone and cartilage tissue engineering
title_sort applications of decellularized extracellular matrix in bone and cartilage tissue engineering
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336671/
https://www.ncbi.nlm.nih.gov/pubmed/30680321
http://dx.doi.org/10.1002/btm2.10110
work_keys_str_mv AT kimyuseon applicationsofdecellularizedextracellularmatrixinboneandcartilagetissueengineering
AT majidmarjan applicationsofdecellularizedextracellularmatrixinboneandcartilagetissueengineering
AT melchiorrianthonyj applicationsofdecellularizedextracellularmatrixinboneandcartilagetissueengineering
AT mikosantoniosg applicationsofdecellularizedextracellularmatrixinboneandcartilagetissueengineering