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tACS motor system effects can be caused by transcutaneous stimulation of peripheral nerves
Transcranial alternating current stimulation (tACS) is a noninvasive neuromodulation method which has been shown to modulate hearing, motor, cognitive and memory function. However, the mechanisms underpinning these findings are controversial, as studies show that the current reaching the cortex may...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336776/ https://www.ncbi.nlm.nih.gov/pubmed/30655523 http://dx.doi.org/10.1038/s41467-018-08183-w |
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author | Asamoah, Boateng Khatoun, Ahmad Mc Laughlin, Myles |
author_facet | Asamoah, Boateng Khatoun, Ahmad Mc Laughlin, Myles |
author_sort | Asamoah, Boateng |
collection | PubMed |
description | Transcranial alternating current stimulation (tACS) is a noninvasive neuromodulation method which has been shown to modulate hearing, motor, cognitive and memory function. However, the mechanisms underpinning these findings are controversial, as studies show that the current reaching the cortex may not be strong enough to entrain neural activity. Here, we propose a new hypothesis to reconcile these opposing results: tACS effects are caused by transcutaneous stimulation of peripheral nerves in the skin and not transcranial stimulation of cortical neurons. Rhythmic activity from peripheral nerves then entrains cortical neurons. A series of experiments in rats and humans isolated the transcranial and transcutaneous mechanisms and showed that the reported effects of tACS on the motor system can be caused by transcutaneous stimulation of peripheral nerves. Whether or not the transcutaneous mechanism will generalize to tACS effects on other systems is debatable but should be investigated. |
format | Online Article Text |
id | pubmed-6336776 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-63367762019-01-22 tACS motor system effects can be caused by transcutaneous stimulation of peripheral nerves Asamoah, Boateng Khatoun, Ahmad Mc Laughlin, Myles Nat Commun Article Transcranial alternating current stimulation (tACS) is a noninvasive neuromodulation method which has been shown to modulate hearing, motor, cognitive and memory function. However, the mechanisms underpinning these findings are controversial, as studies show that the current reaching the cortex may not be strong enough to entrain neural activity. Here, we propose a new hypothesis to reconcile these opposing results: tACS effects are caused by transcutaneous stimulation of peripheral nerves in the skin and not transcranial stimulation of cortical neurons. Rhythmic activity from peripheral nerves then entrains cortical neurons. A series of experiments in rats and humans isolated the transcranial and transcutaneous mechanisms and showed that the reported effects of tACS on the motor system can be caused by transcutaneous stimulation of peripheral nerves. Whether or not the transcutaneous mechanism will generalize to tACS effects on other systems is debatable but should be investigated. Nature Publishing Group UK 2019-01-17 /pmc/articles/PMC6336776/ /pubmed/30655523 http://dx.doi.org/10.1038/s41467-018-08183-w Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Asamoah, Boateng Khatoun, Ahmad Mc Laughlin, Myles tACS motor system effects can be caused by transcutaneous stimulation of peripheral nerves |
title | tACS motor system effects can be caused by transcutaneous stimulation of peripheral nerves |
title_full | tACS motor system effects can be caused by transcutaneous stimulation of peripheral nerves |
title_fullStr | tACS motor system effects can be caused by transcutaneous stimulation of peripheral nerves |
title_full_unstemmed | tACS motor system effects can be caused by transcutaneous stimulation of peripheral nerves |
title_short | tACS motor system effects can be caused by transcutaneous stimulation of peripheral nerves |
title_sort | tacs motor system effects can be caused by transcutaneous stimulation of peripheral nerves |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336776/ https://www.ncbi.nlm.nih.gov/pubmed/30655523 http://dx.doi.org/10.1038/s41467-018-08183-w |
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