A genome-wide CRISPR screen identifies N-acetylglucosamine-1-phosphate transferase as a potential antiviral target for Ebola virus

There are no approved therapies for Ebola virus infection. Here, to find potential therapeutic targets, we perform a screen for genes essential for Ebola virus (EBOV) infection. We identify GNPTAB, which encodes the α and β subunits of N-acetylglucosamine-1-phosphate transferase. We show that EBOV i...

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Detalles Bibliográficos
Autores principales: Flint, Mike, Chatterjee, Payel, Lin, David L., McMullan, Laura K., Shrivastava-Ranjan, Punya, Bergeron, Éric, Lo, Michael K., Welch, Stephen R., Nichol, Stuart T., Tai, Andrew W., Spiropoulou, Christina F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336797/
https://www.ncbi.nlm.nih.gov/pubmed/30655525
http://dx.doi.org/10.1038/s41467-018-08135-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336797/
https://www.ncbi.nlm.nih.gov/pubmed/30655525
http://dx.doi.org/10.1038/s41467-018-08135-4

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