Cargando…
Trigeminal nociceptive function and oral somatosensory functional and structural assessment in patients with diabetic peripheral neuropathy
This case-control study primarily compared the trigeminal nociceptive function, the intraoral somatosensory profile and possible structural nerve changes between diabetic peripheral neuropathy (DPN, n = 12) patients and healthy participants (n = 12). The nociceptive blink reflex (nBR) was recorded a...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336810/ https://www.ncbi.nlm.nih.gov/pubmed/30655584 http://dx.doi.org/10.1038/s41598-018-37041-4 |
_version_ | 1783388121897893888 |
---|---|
author | Costa, Y. M. Karlsson, P. Bonjardim, L. R. Conti, P. C. R. Tankisi, H. Jensen, T. S. Nyengaard, J. R. Svensson, P. Baad-Hansen, L. |
author_facet | Costa, Y. M. Karlsson, P. Bonjardim, L. R. Conti, P. C. R. Tankisi, H. Jensen, T. S. Nyengaard, J. R. Svensson, P. Baad-Hansen, L. |
author_sort | Costa, Y. M. |
collection | PubMed |
description | This case-control study primarily compared the trigeminal nociceptive function, the intraoral somatosensory profile and possible structural nerve changes between diabetic peripheral neuropathy (DPN, n = 12) patients and healthy participants (n = 12). The nociceptive blink reflex (nBR) was recorded applying an electrical stimulation over the entry zone of the right supraorbital (V1R), infraorbital (V2R) and mental (V3R) and left infraorbital (V2L) nerves. The outcomes were: individual electrical sensory (I(0)) and pain thresholds (I(P)); root mean square (RMS), area-under-the-curve (AUC) and onset latencies of R2 component of the nBR. Furthermore, a standardized full battery of quantitative sensory testing (QST) and intraepidermal nerve fibre density (IENFD) or nerve fibre length density (NFLD) assessment were performed, respectively, on the distal leg and oral mucosa. As expected, all patients had altered somatosensory sensitivity and lower IENFD in the lower limb. DPN patients presented higher I(0), I(P), RMS and AUC values (p < 0.050), lower warm detection thresholds (WDT) (p = 0.004), higher occurrence of paradoxical heat sensation (PHS) (p = 0.040), and a lower intraoral NFLD (p = 0.048) than the healthy participants. In addition, the presence of any abnormal intraoral somatosensory finding was more frequent in the DPN patients when compared to the reference group (p = 0.013). Early signs of trigeminal nociceptive facilitation, intraoral somatosensory abnormalities and loss of intraoral neuronal tissue can be detected in DPN patients. |
format | Online Article Text |
id | pubmed-6336810 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-63368102019-01-22 Trigeminal nociceptive function and oral somatosensory functional and structural assessment in patients with diabetic peripheral neuropathy Costa, Y. M. Karlsson, P. Bonjardim, L. R. Conti, P. C. R. Tankisi, H. Jensen, T. S. Nyengaard, J. R. Svensson, P. Baad-Hansen, L. Sci Rep Article This case-control study primarily compared the trigeminal nociceptive function, the intraoral somatosensory profile and possible structural nerve changes between diabetic peripheral neuropathy (DPN, n = 12) patients and healthy participants (n = 12). The nociceptive blink reflex (nBR) was recorded applying an electrical stimulation over the entry zone of the right supraorbital (V1R), infraorbital (V2R) and mental (V3R) and left infraorbital (V2L) nerves. The outcomes were: individual electrical sensory (I(0)) and pain thresholds (I(P)); root mean square (RMS), area-under-the-curve (AUC) and onset latencies of R2 component of the nBR. Furthermore, a standardized full battery of quantitative sensory testing (QST) and intraepidermal nerve fibre density (IENFD) or nerve fibre length density (NFLD) assessment were performed, respectively, on the distal leg and oral mucosa. As expected, all patients had altered somatosensory sensitivity and lower IENFD in the lower limb. DPN patients presented higher I(0), I(P), RMS and AUC values (p < 0.050), lower warm detection thresholds (WDT) (p = 0.004), higher occurrence of paradoxical heat sensation (PHS) (p = 0.040), and a lower intraoral NFLD (p = 0.048) than the healthy participants. In addition, the presence of any abnormal intraoral somatosensory finding was more frequent in the DPN patients when compared to the reference group (p = 0.013). Early signs of trigeminal nociceptive facilitation, intraoral somatosensory abnormalities and loss of intraoral neuronal tissue can be detected in DPN patients. Nature Publishing Group UK 2019-01-17 /pmc/articles/PMC6336810/ /pubmed/30655584 http://dx.doi.org/10.1038/s41598-018-37041-4 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Costa, Y. M. Karlsson, P. Bonjardim, L. R. Conti, P. C. R. Tankisi, H. Jensen, T. S. Nyengaard, J. R. Svensson, P. Baad-Hansen, L. Trigeminal nociceptive function and oral somatosensory functional and structural assessment in patients with diabetic peripheral neuropathy |
title | Trigeminal nociceptive function and oral somatosensory functional and structural assessment in patients with diabetic peripheral neuropathy |
title_full | Trigeminal nociceptive function and oral somatosensory functional and structural assessment in patients with diabetic peripheral neuropathy |
title_fullStr | Trigeminal nociceptive function and oral somatosensory functional and structural assessment in patients with diabetic peripheral neuropathy |
title_full_unstemmed | Trigeminal nociceptive function and oral somatosensory functional and structural assessment in patients with diabetic peripheral neuropathy |
title_short | Trigeminal nociceptive function and oral somatosensory functional and structural assessment in patients with diabetic peripheral neuropathy |
title_sort | trigeminal nociceptive function and oral somatosensory functional and structural assessment in patients with diabetic peripheral neuropathy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336810/ https://www.ncbi.nlm.nih.gov/pubmed/30655584 http://dx.doi.org/10.1038/s41598-018-37041-4 |
work_keys_str_mv | AT costaym trigeminalnociceptivefunctionandoralsomatosensoryfunctionalandstructuralassessmentinpatientswithdiabeticperipheralneuropathy AT karlssonp trigeminalnociceptivefunctionandoralsomatosensoryfunctionalandstructuralassessmentinpatientswithdiabeticperipheralneuropathy AT bonjardimlr trigeminalnociceptivefunctionandoralsomatosensoryfunctionalandstructuralassessmentinpatientswithdiabeticperipheralneuropathy AT contipcr trigeminalnociceptivefunctionandoralsomatosensoryfunctionalandstructuralassessmentinpatientswithdiabeticperipheralneuropathy AT tankisih trigeminalnociceptivefunctionandoralsomatosensoryfunctionalandstructuralassessmentinpatientswithdiabeticperipheralneuropathy AT jensents trigeminalnociceptivefunctionandoralsomatosensoryfunctionalandstructuralassessmentinpatientswithdiabeticperipheralneuropathy AT nyengaardjr trigeminalnociceptivefunctionandoralsomatosensoryfunctionalandstructuralassessmentinpatientswithdiabeticperipheralneuropathy AT svenssonp trigeminalnociceptivefunctionandoralsomatosensoryfunctionalandstructuralassessmentinpatientswithdiabeticperipheralneuropathy AT baadhansenl trigeminalnociceptivefunctionandoralsomatosensoryfunctionalandstructuralassessmentinpatientswithdiabeticperipheralneuropathy |