Centenarian controls increase variant effect sizes by an average twofold in an extreme case–extreme control analysis of Alzheimer’s disease

The detection of genetic loci associated with Alzheimer’s disease (AD) requires large numbers of cases and controls because variant effect sizes are mostly small. We hypothesized that variant effect sizes should increase when individuals who represent the extreme ends of a disease spectrum are consi...

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Detalles Bibliográficos
Autores principales: Tesi, Niccolò, van der Lee, Sven J., Hulsman, Marc, Jansen, Iris E., Stringa, Najada, van Schoor, Natasja, Meijers-Heijboer, Hanne, Huisman, Martijn, Scheltens, Philip, Reinders, Marcel J. T., van der Flier, Wiesje M., Holstege, Henne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336855/
https://www.ncbi.nlm.nih.gov/pubmed/30258121
http://dx.doi.org/10.1038/s41431-018-0273-5

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