Setd5 haploinsufficiency alters neuronal network connectivity and leads to autistic-like behaviors in mice

SETD5, a gene linked to intellectual disability (ID) and autism spectrum disorder (ASD), is a member of the SET-domain family and encodes a putative histone methyltransferase (HMT). To date, the mechanism by which SETD5 haploinsufficiency causes ASD/ID remains an unanswered question. Setd5 is the hi...

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Detalles Bibliográficos
Autores principales: Moore, Spencer M., Seidman, Jason S., Ellegood, Jacob, Gao, Richard, Savchenko, Alex, Troutman, Ty D., Abe, Yohei, Stender, Josh, Lee, Daehoon, Wang, Sicong, Voytek, Bradley, Lerch, Jason P., Suh, Hoonkyo, Glass, Christopher K, Muotri, Alysson R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336863/
https://www.ncbi.nlm.nih.gov/pubmed/30655503
http://dx.doi.org/10.1038/s41398-018-0344-y

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