Fetal glucocorticoid receptor (Nr3c1) deficiency alters the landscape of DNA methylation of murine placenta in a sex-dependent manner and is associated to anxiety-like behavior in adulthood

Prenatal stress defines long-term phenotypes through epigenetic programming of the offspring. These effects are potentially mediated by glucocorticoid release and by sex. We hypothesized that the glucocorticoid receptor (Gr, Nr3c1) fashions the DNA methylation profile of offspring. Consistent with t...

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Detalles Bibliográficos
Autores principales: Schmidt, Michaela, Lax, Elad, Zhou, Rudy, Cheishvili, David, Ruder, Arne Mathias, Ludiro, Alessia, Lapert, Florian, Macedo da Cruz, Anna, Sandrini, Paolo, Calzoni, Teresa, Vaisheva, Farida, Brandwein, Christiane, Luoni, Alessia, Massart, Renaud, Lanfumey, Laurence, Riva, Marco Andrea, Deuschle, Michael, Gass, Peter, Szyf, Moshe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336883/
https://www.ncbi.nlm.nih.gov/pubmed/30655507
http://dx.doi.org/10.1038/s41398-018-0348-7

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