A novel tankyrase inhibitor, MSC2504877, enhances the effects of clinical CDK4/6 inhibitors

Inhibition of the PARP superfamily tankyrase enzymes suppresses Wnt/β-catenin signalling in tumour cells. Here, we describe here a novel, drug-like small molecule inhibitor of tankyrase MSC2504877 that inhibits the growth of APC mutant colorectal tumour cells. Parallel siRNA and drug sensitivity scr...

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Detalles Bibliográficos
Autores principales: Menon, Malini, Elliott, Richard, Bowers, Leandra, Balan, Nicolae, Rafiq, Rumana, Costa-Cabral, Sara, Munkonge, Felix, Trinidade, Ines, Porter, Roderick, Campbell, Andrew D., Johnson, Emma R., Esdar, Christina, Buchstaller, Hans-Peter, Leuthner, Birgitta, Rohdich, Felix, Schneider, Richard, Sansom, Owen, Wienke, Dirk, Ashworth, Alan, Lord, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336890/
https://www.ncbi.nlm.nih.gov/pubmed/30655555
http://dx.doi.org/10.1038/s41598-018-36447-4

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