Whole genome sequencing suggests transmission of Corynebacterium diphtheriae-caused cutaneous diphtheria in two siblings, Germany, 2018

In September 2018, a child who had returned from Somalia to Germany presented with cutaneous diphtheria by toxigenic Corynebacterium diphtheriae biovar mitis. The child’s sibling had superinfected insect bites harbouring also toxigenic C. diphtheriae. Next generation sequencing (NGS) revealed the sa...

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Detalles Bibliográficos
Autores principales: Berger, Anja, Dangel, Alexandra, Schober, Tilmann, Schmidbauer, Birgit, Konrad, Regina, Marosevic, Durdica, Schubert, Sören, Hörmansdorfer, Stefan, Ackermann, Nikolaus, Hübner, Johannes, Sing, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2019
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337054/
https://www.ncbi.nlm.nih.gov/pubmed/30646974
http://dx.doi.org/10.2807/1560-7917.ES.2019.24.2.1800683
Descripción
Sumario:In September 2018, a child who had returned from Somalia to Germany presented with cutaneous diphtheria by toxigenic Corynebacterium diphtheriae biovar mitis. The child’s sibling had superinfected insect bites harbouring also toxigenic C. diphtheriae. Next generation sequencing (NGS) revealed the same strain in both patients suggesting very recent human-to-human transmission. Epidemiological and NGS data suggest that the two cutaneous diphtheria cases constitute the first outbreak by toxigenic C. diphtheriae in Germany since the 1980s.

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