Whole genome sequencing suggests transmission of Corynebacterium diphtheriae-caused cutaneous diphtheria in two siblings, Germany, 2018

In September 2018, a child who had returned from Somalia to Germany presented with cutaneous diphtheria by toxigenic Corynebacterium diphtheriae biovar mitis. The child’s sibling had superinfected insect bites harbouring also toxigenic C. diphtheriae. Next generation sequencing (NGS) revealed the sa...

Descripción completa

Detalles Bibliográficos
Autores principales: Berger, Anja, Dangel, Alexandra, Schober, Tilmann, Schmidbauer, Birgit, Konrad, Regina, Marosevic, Durdica, Schubert, Sören, Hörmansdorfer, Stefan, Ackermann, Nikolaus, Hübner, Johannes, Sing, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2019
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337054/
https://www.ncbi.nlm.nih.gov/pubmed/30646974
http://dx.doi.org/10.2807/1560-7917.ES.2019.24.2.1800683
_version_ 1783388156107685888
author Berger, Anja
Dangel, Alexandra
Schober, Tilmann
Schmidbauer, Birgit
Konrad, Regina
Marosevic, Durdica
Schubert, Sören
Hörmansdorfer, Stefan
Ackermann, Nikolaus
Hübner, Johannes
Sing, Andreas
author_facet Berger, Anja
Dangel, Alexandra
Schober, Tilmann
Schmidbauer, Birgit
Konrad, Regina
Marosevic, Durdica
Schubert, Sören
Hörmansdorfer, Stefan
Ackermann, Nikolaus
Hübner, Johannes
Sing, Andreas
author_sort Berger, Anja
collection PubMed
description In September 2018, a child who had returned from Somalia to Germany presented with cutaneous diphtheria by toxigenic Corynebacterium diphtheriae biovar mitis. The child’s sibling had superinfected insect bites harbouring also toxigenic C. diphtheriae. Next generation sequencing (NGS) revealed the same strain in both patients suggesting very recent human-to-human transmission. Epidemiological and NGS data suggest that the two cutaneous diphtheria cases constitute the first outbreak by toxigenic C. diphtheriae in Germany since the 1980s.
format Online
Article
Text
id pubmed-6337054
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher European Centre for Disease Prevention and Control (ECDC)
record_format MEDLINE/PubMed
spelling pubmed-63370542019-02-08 Whole genome sequencing suggests transmission of Corynebacterium diphtheriae-caused cutaneous diphtheria in two siblings, Germany, 2018 Berger, Anja Dangel, Alexandra Schober, Tilmann Schmidbauer, Birgit Konrad, Regina Marosevic, Durdica Schubert, Sören Hörmansdorfer, Stefan Ackermann, Nikolaus Hübner, Johannes Sing, Andreas Euro Surveill Rapid Communication In September 2018, a child who had returned from Somalia to Germany presented with cutaneous diphtheria by toxigenic Corynebacterium diphtheriae biovar mitis. The child’s sibling had superinfected insect bites harbouring also toxigenic C. diphtheriae. Next generation sequencing (NGS) revealed the same strain in both patients suggesting very recent human-to-human transmission. Epidemiological and NGS data suggest that the two cutaneous diphtheria cases constitute the first outbreak by toxigenic C. diphtheriae in Germany since the 1980s. European Centre for Disease Prevention and Control (ECDC) 2019-01-10 /pmc/articles/PMC6337054/ /pubmed/30646974 http://dx.doi.org/10.2807/1560-7917.ES.2019.24.2.1800683 Text en This article is copyright of The Authors, 2019. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.
spellingShingle Rapid Communication
Berger, Anja
Dangel, Alexandra
Schober, Tilmann
Schmidbauer, Birgit
Konrad, Regina
Marosevic, Durdica
Schubert, Sören
Hörmansdorfer, Stefan
Ackermann, Nikolaus
Hübner, Johannes
Sing, Andreas
Whole genome sequencing suggests transmission of Corynebacterium diphtheriae-caused cutaneous diphtheria in two siblings, Germany, 2018
title Whole genome sequencing suggests transmission of Corynebacterium diphtheriae-caused cutaneous diphtheria in two siblings, Germany, 2018
title_full Whole genome sequencing suggests transmission of Corynebacterium diphtheriae-caused cutaneous diphtheria in two siblings, Germany, 2018
title_fullStr Whole genome sequencing suggests transmission of Corynebacterium diphtheriae-caused cutaneous diphtheria in two siblings, Germany, 2018
title_full_unstemmed Whole genome sequencing suggests transmission of Corynebacterium diphtheriae-caused cutaneous diphtheria in two siblings, Germany, 2018
title_short Whole genome sequencing suggests transmission of Corynebacterium diphtheriae-caused cutaneous diphtheria in two siblings, Germany, 2018
title_sort whole genome sequencing suggests transmission of corynebacterium diphtheriae-caused cutaneous diphtheria in two siblings, germany, 2018
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337054/
https://www.ncbi.nlm.nih.gov/pubmed/30646974
http://dx.doi.org/10.2807/1560-7917.ES.2019.24.2.1800683
work_keys_str_mv AT bergeranja wholegenomesequencingsuggeststransmissionofcorynebacteriumdiphtheriaecausedcutaneousdiphtheriaintwosiblingsgermany2018
AT dangelalexandra wholegenomesequencingsuggeststransmissionofcorynebacteriumdiphtheriaecausedcutaneousdiphtheriaintwosiblingsgermany2018
AT schobertilmann wholegenomesequencingsuggeststransmissionofcorynebacteriumdiphtheriaecausedcutaneousdiphtheriaintwosiblingsgermany2018
AT schmidbauerbirgit wholegenomesequencingsuggeststransmissionofcorynebacteriumdiphtheriaecausedcutaneousdiphtheriaintwosiblingsgermany2018
AT konradregina wholegenomesequencingsuggeststransmissionofcorynebacteriumdiphtheriaecausedcutaneousdiphtheriaintwosiblingsgermany2018
AT marosevicdurdica wholegenomesequencingsuggeststransmissionofcorynebacteriumdiphtheriaecausedcutaneousdiphtheriaintwosiblingsgermany2018
AT schubertsoren wholegenomesequencingsuggeststransmissionofcorynebacteriumdiphtheriaecausedcutaneousdiphtheriaintwosiblingsgermany2018
AT hormansdorferstefan wholegenomesequencingsuggeststransmissionofcorynebacteriumdiphtheriaecausedcutaneousdiphtheriaintwosiblingsgermany2018
AT ackermannnikolaus wholegenomesequencingsuggeststransmissionofcorynebacteriumdiphtheriaecausedcutaneousdiphtheriaintwosiblingsgermany2018
AT hubnerjohannes wholegenomesequencingsuggeststransmissionofcorynebacteriumdiphtheriaecausedcutaneousdiphtheriaintwosiblingsgermany2018
AT singandreas wholegenomesequencingsuggeststransmissionofcorynebacteriumdiphtheriaecausedcutaneousdiphtheriaintwosiblingsgermany2018

Ejemplares similares