The Influence of Capsaicin on the Integrity of Microvascular Endothelial Cell Monolayers

Microvascular endothelial cells are an essential part of many biological barriers, such as the blood–brain barrier (BBB) and the endothelium of the arteries and veins. A reversible opening strategy to increase the permeability of drugs across the BBB could lead to improved therapies due to enhanced...

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Autores principales: Kaiser, Mathias, Burek, Malgorzata, Britz, Stefan, Lankamp, Frauke, Ketelhut, Steffi, Kemper, Björn, Förster, Carola, Gorzelanny, Christian, Goycoolea, Francisco M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337111/
https://www.ncbi.nlm.nih.gov/pubmed/30598013
http://dx.doi.org/10.3390/ijms20010122
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author Kaiser, Mathias
Burek, Malgorzata
Britz, Stefan
Lankamp, Frauke
Ketelhut, Steffi
Kemper, Björn
Förster, Carola
Gorzelanny, Christian
Goycoolea, Francisco M.
author_facet Kaiser, Mathias
Burek, Malgorzata
Britz, Stefan
Lankamp, Frauke
Ketelhut, Steffi
Kemper, Björn
Förster, Carola
Gorzelanny, Christian
Goycoolea, Francisco M.
author_sort Kaiser, Mathias
collection PubMed
description Microvascular endothelial cells are an essential part of many biological barriers, such as the blood–brain barrier (BBB) and the endothelium of the arteries and veins. A reversible opening strategy to increase the permeability of drugs across the BBB could lead to improved therapies due to enhanced drug bioavailability. Vanilloids, such as capsaicin, are known to reversibly open tight junctions of epithelial and endothelial cells. In this study, we used several in vitro assays with the murine endothelial capillary brain cells (line cEND) as a BBB model to characterize the interaction between capsaicin and endothelial tight junctions.
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spelling pubmed-63371112019-01-22 The Influence of Capsaicin on the Integrity of Microvascular Endothelial Cell Monolayers Kaiser, Mathias Burek, Malgorzata Britz, Stefan Lankamp, Frauke Ketelhut, Steffi Kemper, Björn Förster, Carola Gorzelanny, Christian Goycoolea, Francisco M. Int J Mol Sci Communication Microvascular endothelial cells are an essential part of many biological barriers, such as the blood–brain barrier (BBB) and the endothelium of the arteries and veins. A reversible opening strategy to increase the permeability of drugs across the BBB could lead to improved therapies due to enhanced drug bioavailability. Vanilloids, such as capsaicin, are known to reversibly open tight junctions of epithelial and endothelial cells. In this study, we used several in vitro assays with the murine endothelial capillary brain cells (line cEND) as a BBB model to characterize the interaction between capsaicin and endothelial tight junctions. MDPI 2018-12-30 /pmc/articles/PMC6337111/ /pubmed/30598013 http://dx.doi.org/10.3390/ijms20010122 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Kaiser, Mathias
Burek, Malgorzata
Britz, Stefan
Lankamp, Frauke
Ketelhut, Steffi
Kemper, Björn
Förster, Carola
Gorzelanny, Christian
Goycoolea, Francisco M.
The Influence of Capsaicin on the Integrity of Microvascular Endothelial Cell Monolayers
title The Influence of Capsaicin on the Integrity of Microvascular Endothelial Cell Monolayers
title_full The Influence of Capsaicin on the Integrity of Microvascular Endothelial Cell Monolayers
title_fullStr The Influence of Capsaicin on the Integrity of Microvascular Endothelial Cell Monolayers
title_full_unstemmed The Influence of Capsaicin on the Integrity of Microvascular Endothelial Cell Monolayers
title_short The Influence of Capsaicin on the Integrity of Microvascular Endothelial Cell Monolayers
title_sort influence of capsaicin on the integrity of microvascular endothelial cell monolayers
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337111/
https://www.ncbi.nlm.nih.gov/pubmed/30598013
http://dx.doi.org/10.3390/ijms20010122
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