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Oxyresveratrol Increases Energy Expenditure through Foxo3a-Mediated Ucp1 Induction in High-Fat-Diet-Induced Obese Mice

The phytochemical oxyresveratrol has been shown to exert diverse biological activities including prevention of obesity. However, the exact reason underlying the anti-obese effects of oxyresveratrol is not fully understood. Here, we investigated the effects and mechanism of oxyresveratrol in adipocyt...

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Autores principales: Choi, Jin Hee, Song, No-Joon, Lee, A Reum, Lee, Dong Ho, Seo, Min-Ju, Kim, Suji, Chang, Seo-Hyuk, Yang, Dong Kwon, Hwang, Yu-Jin, Hwang, Kyung-A, Ha, Tal Soo, Yun, Ui Jeong, Park, Kye Won
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337118/
https://www.ncbi.nlm.nih.gov/pubmed/30577593
http://dx.doi.org/10.3390/ijms20010026
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author Choi, Jin Hee
Song, No-Joon
Lee, A Reum
Lee, Dong Ho
Seo, Min-Ju
Kim, Suji
Chang, Seo-Hyuk
Yang, Dong Kwon
Hwang, Yu-Jin
Hwang, Kyung-A
Ha, Tal Soo
Yun, Ui Jeong
Park, Kye Won
author_facet Choi, Jin Hee
Song, No-Joon
Lee, A Reum
Lee, Dong Ho
Seo, Min-Ju
Kim, Suji
Chang, Seo-Hyuk
Yang, Dong Kwon
Hwang, Yu-Jin
Hwang, Kyung-A
Ha, Tal Soo
Yun, Ui Jeong
Park, Kye Won
author_sort Choi, Jin Hee
collection PubMed
description The phytochemical oxyresveratrol has been shown to exert diverse biological activities including prevention of obesity. However, the exact reason underlying the anti-obese effects of oxyresveratrol is not fully understood. Here, we investigated the effects and mechanism of oxyresveratrol in adipocytes and high-fat diet (HFD)-fed obese mice. Oxyresveratrol suppressed lipid accumulation and expression of adipocyte markers during the adipocyte differentiation of 3T3-L1 and C3H10T1/2 cells. Administration of oxyresveratrol in HFD-fed obese mice prevented body-weight gains, lowered adipose tissue weights, improved lipid profiles, and increased glucose tolerance. The anti-obese effects were linked to increases in energy expenditure and higher rectal temperatures without affecting food intake, fecal lipid content, and physical activity. The increased energy expenditure by oxyresveratrol was concordant with the induction of thermogenic genes including Ucp1, and the reduction of white adipocyte selective genes in adipose tissue. Furthermore, Foxo3a was identified as an oxyresveratrol-induced gene and it mimicked the effects of oxyresveratrol for induction of thermogenic genes and suppression of white adipocyte selective genes, suggesting the role of Foxo3a in oxyresveratrol-mediated anti-obese effects. Taken together, these data show that oxyresveratrol increases energy expenditure through the induction of thermogenic genes in adipose tissue and further implicates oxyresveratrol as an ingredient and Foxo3a as a molecular target for the development of functional foods in obesity and metabolic diseases.
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spelling pubmed-63371182019-01-22 Oxyresveratrol Increases Energy Expenditure through Foxo3a-Mediated Ucp1 Induction in High-Fat-Diet-Induced Obese Mice Choi, Jin Hee Song, No-Joon Lee, A Reum Lee, Dong Ho Seo, Min-Ju Kim, Suji Chang, Seo-Hyuk Yang, Dong Kwon Hwang, Yu-Jin Hwang, Kyung-A Ha, Tal Soo Yun, Ui Jeong Park, Kye Won Int J Mol Sci Article The phytochemical oxyresveratrol has been shown to exert diverse biological activities including prevention of obesity. However, the exact reason underlying the anti-obese effects of oxyresveratrol is not fully understood. Here, we investigated the effects and mechanism of oxyresveratrol in adipocytes and high-fat diet (HFD)-fed obese mice. Oxyresveratrol suppressed lipid accumulation and expression of adipocyte markers during the adipocyte differentiation of 3T3-L1 and C3H10T1/2 cells. Administration of oxyresveratrol in HFD-fed obese mice prevented body-weight gains, lowered adipose tissue weights, improved lipid profiles, and increased glucose tolerance. The anti-obese effects were linked to increases in energy expenditure and higher rectal temperatures without affecting food intake, fecal lipid content, and physical activity. The increased energy expenditure by oxyresveratrol was concordant with the induction of thermogenic genes including Ucp1, and the reduction of white adipocyte selective genes in adipose tissue. Furthermore, Foxo3a was identified as an oxyresveratrol-induced gene and it mimicked the effects of oxyresveratrol for induction of thermogenic genes and suppression of white adipocyte selective genes, suggesting the role of Foxo3a in oxyresveratrol-mediated anti-obese effects. Taken together, these data show that oxyresveratrol increases energy expenditure through the induction of thermogenic genes in adipose tissue and further implicates oxyresveratrol as an ingredient and Foxo3a as a molecular target for the development of functional foods in obesity and metabolic diseases. MDPI 2018-12-21 /pmc/articles/PMC6337118/ /pubmed/30577593 http://dx.doi.org/10.3390/ijms20010026 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Choi, Jin Hee
Song, No-Joon
Lee, A Reum
Lee, Dong Ho
Seo, Min-Ju
Kim, Suji
Chang, Seo-Hyuk
Yang, Dong Kwon
Hwang, Yu-Jin
Hwang, Kyung-A
Ha, Tal Soo
Yun, Ui Jeong
Park, Kye Won
Oxyresveratrol Increases Energy Expenditure through Foxo3a-Mediated Ucp1 Induction in High-Fat-Diet-Induced Obese Mice
title Oxyresveratrol Increases Energy Expenditure through Foxo3a-Mediated Ucp1 Induction in High-Fat-Diet-Induced Obese Mice
title_full Oxyresveratrol Increases Energy Expenditure through Foxo3a-Mediated Ucp1 Induction in High-Fat-Diet-Induced Obese Mice
title_fullStr Oxyresveratrol Increases Energy Expenditure through Foxo3a-Mediated Ucp1 Induction in High-Fat-Diet-Induced Obese Mice
title_full_unstemmed Oxyresveratrol Increases Energy Expenditure through Foxo3a-Mediated Ucp1 Induction in High-Fat-Diet-Induced Obese Mice
title_short Oxyresveratrol Increases Energy Expenditure through Foxo3a-Mediated Ucp1 Induction in High-Fat-Diet-Induced Obese Mice
title_sort oxyresveratrol increases energy expenditure through foxo3a-mediated ucp1 induction in high-fat-diet-induced obese mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337118/
https://www.ncbi.nlm.nih.gov/pubmed/30577593
http://dx.doi.org/10.3390/ijms20010026
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