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Molecules that Inhibit Bacterial Resistance Enzymes

Antibiotic resistance mediated by bacterial enzymes constitutes an unmet clinical challenge for public health, particularly for those currently used antibiotics that are recognized as “last-resort” defense against multidrug-resistant (MDR) bacteria. Inhibitors of resistance enzymes offer an alternat...

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Detalles Bibliográficos
Autores principales: Liu, Yuan, Li, Ruichao, Xiao, Xia, Wang, Zhiqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337270/
https://www.ncbi.nlm.nih.gov/pubmed/30583527
http://dx.doi.org/10.3390/molecules24010043
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author Liu, Yuan
Li, Ruichao
Xiao, Xia
Wang, Zhiqiang
author_facet Liu, Yuan
Li, Ruichao
Xiao, Xia
Wang, Zhiqiang
author_sort Liu, Yuan
collection PubMed
description Antibiotic resistance mediated by bacterial enzymes constitutes an unmet clinical challenge for public health, particularly for those currently used antibiotics that are recognized as “last-resort” defense against multidrug-resistant (MDR) bacteria. Inhibitors of resistance enzymes offer an alternative strategy to counter this threat. The combination of inhibitors and antibiotics could effectively prolong the lifespan of clinically relevant antibiotics and minimize the impact and emergence of resistance. In this review, we first provide a brief overview of antibiotic resistance mechanism by bacterial secreted enzymes. Furthermore, we summarize the potential inhibitors that sabotage these resistance pathways and restore the bactericidal activity of inactive antibiotics. Finally, the faced challenges and an outlook for the development of more effective and safer resistance enzyme inhibitors are discussed.
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spelling pubmed-63372702019-01-25 Molecules that Inhibit Bacterial Resistance Enzymes Liu, Yuan Li, Ruichao Xiao, Xia Wang, Zhiqiang Molecules Review Antibiotic resistance mediated by bacterial enzymes constitutes an unmet clinical challenge for public health, particularly for those currently used antibiotics that are recognized as “last-resort” defense against multidrug-resistant (MDR) bacteria. Inhibitors of resistance enzymes offer an alternative strategy to counter this threat. The combination of inhibitors and antibiotics could effectively prolong the lifespan of clinically relevant antibiotics and minimize the impact and emergence of resistance. In this review, we first provide a brief overview of antibiotic resistance mechanism by bacterial secreted enzymes. Furthermore, we summarize the potential inhibitors that sabotage these resistance pathways and restore the bactericidal activity of inactive antibiotics. Finally, the faced challenges and an outlook for the development of more effective and safer resistance enzyme inhibitors are discussed. MDPI 2018-12-22 /pmc/articles/PMC6337270/ /pubmed/30583527 http://dx.doi.org/10.3390/molecules24010043 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Liu, Yuan
Li, Ruichao
Xiao, Xia
Wang, Zhiqiang
Molecules that Inhibit Bacterial Resistance Enzymes
title Molecules that Inhibit Bacterial Resistance Enzymes
title_full Molecules that Inhibit Bacterial Resistance Enzymes
title_fullStr Molecules that Inhibit Bacterial Resistance Enzymes
title_full_unstemmed Molecules that Inhibit Bacterial Resistance Enzymes
title_short Molecules that Inhibit Bacterial Resistance Enzymes
title_sort molecules that inhibit bacterial resistance enzymes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337270/
https://www.ncbi.nlm.nih.gov/pubmed/30583527
http://dx.doi.org/10.3390/molecules24010043
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