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Molecules that Inhibit Bacterial Resistance Enzymes
Antibiotic resistance mediated by bacterial enzymes constitutes an unmet clinical challenge for public health, particularly for those currently used antibiotics that are recognized as “last-resort” defense against multidrug-resistant (MDR) bacteria. Inhibitors of resistance enzymes offer an alternat...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337270/ https://www.ncbi.nlm.nih.gov/pubmed/30583527 http://dx.doi.org/10.3390/molecules24010043 |
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author | Liu, Yuan Li, Ruichao Xiao, Xia Wang, Zhiqiang |
author_facet | Liu, Yuan Li, Ruichao Xiao, Xia Wang, Zhiqiang |
author_sort | Liu, Yuan |
collection | PubMed |
description | Antibiotic resistance mediated by bacterial enzymes constitutes an unmet clinical challenge for public health, particularly for those currently used antibiotics that are recognized as “last-resort” defense against multidrug-resistant (MDR) bacteria. Inhibitors of resistance enzymes offer an alternative strategy to counter this threat. The combination of inhibitors and antibiotics could effectively prolong the lifespan of clinically relevant antibiotics and minimize the impact and emergence of resistance. In this review, we first provide a brief overview of antibiotic resistance mechanism by bacterial secreted enzymes. Furthermore, we summarize the potential inhibitors that sabotage these resistance pathways and restore the bactericidal activity of inactive antibiotics. Finally, the faced challenges and an outlook for the development of more effective and safer resistance enzyme inhibitors are discussed. |
format | Online Article Text |
id | pubmed-6337270 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-63372702019-01-25 Molecules that Inhibit Bacterial Resistance Enzymes Liu, Yuan Li, Ruichao Xiao, Xia Wang, Zhiqiang Molecules Review Antibiotic resistance mediated by bacterial enzymes constitutes an unmet clinical challenge for public health, particularly for those currently used antibiotics that are recognized as “last-resort” defense against multidrug-resistant (MDR) bacteria. Inhibitors of resistance enzymes offer an alternative strategy to counter this threat. The combination of inhibitors and antibiotics could effectively prolong the lifespan of clinically relevant antibiotics and minimize the impact and emergence of resistance. In this review, we first provide a brief overview of antibiotic resistance mechanism by bacterial secreted enzymes. Furthermore, we summarize the potential inhibitors that sabotage these resistance pathways and restore the bactericidal activity of inactive antibiotics. Finally, the faced challenges and an outlook for the development of more effective and safer resistance enzyme inhibitors are discussed. MDPI 2018-12-22 /pmc/articles/PMC6337270/ /pubmed/30583527 http://dx.doi.org/10.3390/molecules24010043 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Liu, Yuan Li, Ruichao Xiao, Xia Wang, Zhiqiang Molecules that Inhibit Bacterial Resistance Enzymes |
title | Molecules that Inhibit Bacterial Resistance Enzymes |
title_full | Molecules that Inhibit Bacterial Resistance Enzymes |
title_fullStr | Molecules that Inhibit Bacterial Resistance Enzymes |
title_full_unstemmed | Molecules that Inhibit Bacterial Resistance Enzymes |
title_short | Molecules that Inhibit Bacterial Resistance Enzymes |
title_sort | molecules that inhibit bacterial resistance enzymes |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337270/ https://www.ncbi.nlm.nih.gov/pubmed/30583527 http://dx.doi.org/10.3390/molecules24010043 |
work_keys_str_mv | AT liuyuan moleculesthatinhibitbacterialresistanceenzymes AT liruichao moleculesthatinhibitbacterialresistanceenzymes AT xiaoxia moleculesthatinhibitbacterialresistanceenzymes AT wangzhiqiang moleculesthatinhibitbacterialresistanceenzymes |